Matches in SemOpenAlex for { <https://semopenalex.org/work/W1176710159> ?p ?o ?g. }
- W1176710159 abstract "Drug efflux pumps possessed by gram-positive organisms are encoded either by plasmid- or chromosomally-based genes. Generally, drug-specific efflux pumps tend to be located on plasmids and thus are readily transmissible, whereas multidrug (MDR) efflux pumps are usually encoded on the chromosome and are not easily donated to another organism. This chapter focuses the discussion entirely on MDR-type pumps. The available genome sequence data for gram-positive organisms suggests the existence of numerous potential drug pumps in all of them. The greatest amount of information regarding the mechanism(s) of pump function and multidrug recognition as well as the regulation of pump gene expression in gram-positive organisms is available for major facilitator superfamily (MFS) MDR efflux pumps. The study of the mechanism of multidrug recognition and transport is hampered by our general inability to produce high-resolution crystals of MDR pump proteins. Further research on bacterial MDR efflux pumps is warranted in an effort to improve our understanding of how these systems work, because such an understanding may allow the development of means to overcome this resistance mechanism and to recover useful activity of their antibiotic substrates." @default.
- W1176710159 created "2016-06-24" @default.
- W1176710159 creator A5066014473 @default.
- W1176710159 date "2014-04-30" @default.
- W1176710159 modified "2023-09-27" @default.
- W1176710159 title "Role of Multidrug Efflux Pumps in Gram-Positive Bacteria" @default.
- W1176710159 cites W1520166140 @default.
- W1176710159 cites W1521355609 @default.
- W1176710159 cites W1549517261 @default.
- W1176710159 cites W1779791888 @default.
- W1176710159 cites W1844817938 @default.
- W1176710159 cites W1891863203 @default.
- W1176710159 cites W1964365123 @default.
- W1176710159 cites W1969608438 @default.
- W1176710159 cites W1970884855 @default.
- W1176710159 cites W1974640240 @default.
- W1176710159 cites W1978707497 @default.
- W1176710159 cites W1982384142 @default.
- W1176710159 cites W1983887734 @default.
- W1176710159 cites W1984551890 @default.
- W1176710159 cites W1986401262 @default.
- W1176710159 cites W1993063963 @default.
- W1176710159 cites W2001718228 @default.
- W1176710159 cites W2005649513 @default.
- W1176710159 cites W2011657778 @default.
- W1176710159 cites W2014264942 @default.
- W1176710159 cites W2019063268 @default.
- W1176710159 cites W2019567686 @default.
- W1176710159 cites W2021381880 @default.
- W1176710159 cites W2030658423 @default.
- W1176710159 cites W2034883490 @default.
- W1176710159 cites W2041445948 @default.
- W1176710159 cites W2047118695 @default.
- W1176710159 cites W2058200999 @default.
- W1176710159 cites W2058357139 @default.
- W1176710159 cites W2062158257 @default.
- W1176710159 cites W2069814511 @default.
- W1176710159 cites W2071122270 @default.
- W1176710159 cites W2071251528 @default.
- W1176710159 cites W2071749333 @default.
- W1176710159 cites W2072577257 @default.
- W1176710159 cites W2080271815 @default.
- W1176710159 cites W2082429334 @default.
- W1176710159 cites W2095408410 @default.
- W1176710159 cites W2098695824 @default.
- W1176710159 cites W2102351560 @default.
- W1176710159 cites W2104219048 @default.
- W1176710159 cites W2104746217 @default.
- W1176710159 cites W2106192857 @default.
- W1176710159 cites W2108570467 @default.
- W1176710159 cites W2112903691 @default.
- W1176710159 cites W2113513083 @default.
- W1176710159 cites W2114625913 @default.
- W1176710159 cites W2116502086 @default.
- W1176710159 cites W2119373372 @default.
- W1176710159 cites W2124431299 @default.
- W1176710159 cites W2126970381 @default.
- W1176710159 cites W2131729340 @default.
- W1176710159 cites W2134992285 @default.
- W1176710159 cites W2135087037 @default.
- W1176710159 cites W2138956992 @default.
- W1176710159 cites W2140667109 @default.
- W1176710159 cites W2142123742 @default.
- W1176710159 cites W2143683338 @default.
- W1176710159 cites W2144501842 @default.
- W1176710159 cites W2145670383 @default.
- W1176710159 cites W2145962301 @default.
- W1176710159 cites W2147447439 @default.
- W1176710159 cites W2149123067 @default.
- W1176710159 cites W2149771781 @default.
- W1176710159 cites W2152166532 @default.
- W1176710159 cites W2155507761 @default.
- W1176710159 cites W2156442940 @default.
- W1176710159 cites W2158761431 @default.
- W1176710159 cites W2160852967 @default.
- W1176710159 cites W2165983633 @default.
- W1176710159 cites W2167131009 @default.
- W1176710159 cites W2171389096 @default.
- W1176710159 cites W2179964433 @default.
- W1176710159 cites W4253850261 @default.
- W1176710159 doi "https://doi.org/10.1128/9781555817572.ch20" @default.
- W1176710159 hasPublicationYear "2014" @default.
- W1176710159 type Work @default.
- W1176710159 sameAs 1176710159 @default.
- W1176710159 citedByCount "1" @default.
- W1176710159 crossrefType "book-chapter" @default.
- W1176710159 hasAuthorship W1176710159A5066014473 @default.
- W1176710159 hasConcept C104317684 @default.
- W1176710159 hasConcept C114851261 @default.
- W1176710159 hasConcept C133936738 @default.
- W1176710159 hasConcept C137858568 @default.
- W1176710159 hasConcept C14036430 @default.
- W1176710159 hasConcept C149011108 @default.
- W1176710159 hasConcept C200082930 @default.
- W1176710159 hasConcept C22744801 @default.
- W1176710159 hasConcept C54355233 @default.
- W1176710159 hasConcept C62465871 @default.
- W1176710159 hasConcept C70721500 @default.
- W1176710159 hasConcept C86803240 @default.
- W1176710159 hasConcept C89423630 @default.