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- W1176934662 abstract "Introduction: Nephroblastoma (Wilms' tumor - WT) is the most common solid tumor of kidney in children. We present treatment development of WT in the Czech Republic over 30 years period at the Department of Pediatric Hematology and Oncology, Charles University in Prague, 2nd Faculty of Medicine and University Hospital Motol (KDHO). Patients that were treated prior to access to International Society of Pediatric Oncology (SIOP) are considered to be historical group, then according SIOP 9, SIOP 93-01 and SIOP 2001 as full participant of SIOP studies. Patients and methods: Between January 1980 and April 2009 we treated 330 patients with WT at KDHO: historical group (1980-1988) 91 patients, SIOP 9 (1988-1993) 94, SIOP 93-01 (1994-2001) 80 and SIOP 2001 (2002-2009) 65 patients. Overall survival (OS) and event-free survival (EFS) analyzed by Kaplan-Meier test. Results: The overall ten-year EFS is 81.2% and OS 87.6%. 58 patients from 330 (17.6%) had metastases at diagnosis, EFS without metastatic process is 84.6% compared to 65.4% with metastasis presented at diagnosis (p = 0.0003), OS is 70.7% compared to 91.2% (p <0.0001). 170 (51.5%) were treated with preoperative chemotherapy and/or radiotherapy whereas 158 patients (47.5%) underwent primary nephrectomy; EFS and OS do not differ: neoadjuvant versus primary nephrectomy EFS 81.2% vs. 80.9% (p = 0.85), OS 89.4% vs. 85.4% (p = 0.38). 60 (18%) patients experienced disease recurrence; OS after relapse 33%. In the historical group EFS and OS are 85.7% and 91.2%, in patients treated according to the protocol SIOP 9 EFS and OS are 68.1% and 74.5%, SIOP 93-01 83.6% and 93.7% and 87 SIOP 2001 , 7% and 95.4% (p = 0.001 and p = 0.0008). Conclusion: WT is well treatable disease. The aim for the future is to maintain the current very good survival while minimizing the treatment intensity." @default.
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- W1176934662 date "2013-10-15" @default.
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- W1176934662 title "Nefroblastom - 30 let léčby ve Fakultní nemocnici v Motole" @default.
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