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• W117726873 endingPage "40" @default.
• W117726873 startingPage "19" @default.
• W117726873 abstract "ConclusionTLRs have been implicated in the pathogenesis of autoimmune diseases and may have a common role in the initiation of chronic inflammatory conditions. The manifold activities of TLRs allows them to serve a bridging function between the innate and the adaptive immune system, thus making them attractive candidates for a role in RA. The activation of TLRs might be the earliest event in the pathogenic cascade of RA and then through TLR9 autoantibody production may sustain the inflammatory response. The ligand for the initial stimulus that initiates RA still remains elusive. If TLRs are the initial signalling receptors it could be a pathogen or an endogenous TLR ligand released during inflammation or tissue damage, but is likely to be a complex mixture of stimuli.In the last few years data providing evidence of TLR expression and/or upregulation in the synovium of patients with RA has been published, although no functional consequences of their presence in the synovium have yet been demonstrated. More encouraging evidence comes from animal models that demonstrate pathogen initiated models of arthritis, but these data are in contrast with the absence of significant polymorphisms in patients. Overall, TLRs are attractive candidates for the receptors involved in early inflammatory mechanisms of RA, but much more work needs to be done to determine if there is a functional link, and to evaluate the exact role and extent to which they influence disease." @default.
• W117726873 created "2016-06-24" @default.
• W117726873 creator A5013604884 @default.
• W117726873 creator A5047516847 @default.
• W117726873 creator A5056151159 @default.
• W117726873 date "2006-03-15" @default.
• W117726873 modified "2023-10-10" @default.
• W117726873 title "Toll-like receptors and rheumatoid arthritis: is there a connection?" @default.
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