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- W117966670 abstract "Pseudopterosins are marine natural products formed during photosynthesis in a symbiont of the soft coral Pseudopterogorgia elisabethae. Pseudopterosins inhibit phorbol ester (PMA) induced inflammation, release of prostaglandins and leukotrienes from macrophages, and also inhibit degranulation of human PMNs. Pseudopterosins exhibit anti-inflammatory and wound healing properties in several animal models and have shown significant activity in promoting wound healing at donor sites of patients undergoing autologous tissue transplants. At the cellular level, pseudopterosin activity is blocked by pertussis toxin (PTX) pretreatment, indicating that pseudopterosins act upon a G protein or G protein coupled receptor. In this report we provide evidence that pseudopterosins block neutrophil infiltration in PMA treated mouse ears. We also present studies performed with pseudopterosin analogs aimed at defining the pseudopterosin pharmacophore. This research is supported by ARMY grant # W81XWH-06-1-0089." @default.
- W117966670 created "2016-06-24" @default.
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- W117966670 date "2007-04-01" @default.
- W117966670 modified "2023-09-29" @default.
- W117966670 title "Mechanism of action of the Pseudopterosins and their role in wound healing" @default.
- W117966670 doi "https://doi.org/10.1096/fasebj.21.5.a427-d" @default.
- W117966670 hasPublicationYear "2007" @default.
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