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- W1180431076 abstract "This chapter centers on adaptive or antigen-specific cellular responses to xenografts. It emphasizes the nature of T-lymphocyte-dependent immunity to xenografts. Most of the concepts concerning T-cell responses to xenografts developed in the chapter are derived from rodent studies. When considering the T-lymphocyte response to non-self antigens, including xenografts, it is imperative to emphasize the two fundamental properties of T-cell reactions. Although transferred human cells can mediate the rejection of human allografts or porcine xenografts in these animals, they generally fail to initiate vigorous GVHD against the scid mouse host itself. This model of donor MHC-restricted (direct) and host MHC-restricted (indirect) pathways of graft antigen presentation has important implications for the nature of T-cell-dependent immune responses to both allografts and xenografts. Two differing pathways of graft antigen presentation can be envisioned that would fulfill the two-signal requirement for T-cell activation, each involving APC-dependent processes: (i) donor MHC-restricted responses, and (ii) host MHC-restricted responses. CD4-dependent xenograft rejection depends on host and not on donor MHC class II expression. We find that CD4 T cells trigger rapid rejection of rat islet xenografts established in immunodeficient recombinase-activating gene (rag)-deficient hosts. Immunodeficient scid and rag-deficient mice accept tissue and organ xenografts despite retaining innate immune reactivity, including NK-cell function. The precise molecular mechanisms of cellular xenograft rejection remain to be identified, especially regarding the role of particular Th1 and Th2 cytokines in triggering tissue injury." @default.
- W1180431076 created "2016-06-24" @default.
- W1180431076 creator A5018120698 @default.
- W1180431076 date "2014-04-08" @default.
- W1180431076 modified "2023-09-23" @default.
- W1180431076 title "Cellular Immune Responses to Xenografts" @default.
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