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• W1180609160 abstract "Purpose : Leptin is a highly hydrophobic 16-kDa protein encoded by the ob gene which is expre- ssed in adipocytes and participates in the regulation of food intake and energy expenditure. The aims of the present study were to examine the comparison of leptin levels between type I dia- betes mellitus(DM) patients who received exogenous insulin therapy and healthy children, and to find out correlating factors with leptin level in type I DM. Methods : The study was conducted on 34 patients with type I DM and 29 healthy children. Body weight, height, leptin level and body fat percent were measured in both groups. The glycosylated hemoglobin value, C-peptide, insulin level and serum cholesterol were also measured in type I DM. Results : There was no statistically significant difference in mean age, sex distribution and body mass index between the experimental groups, but body fat percent in type I DM was signi- ficantly lower than that of healthy children. The mean leptin levels in male(9.4±6.3ng/mL) and female(17.8±10.2ng/mL) type I DM were significantly higher than in male(6.3±5.7ng/mL) and female(10.2±0.9ng/mL) healthy children(male : P=0.045, female : P=0.005). Serum leptin levels were strongly correlated with the body fat percent(Pearson coefficient)(r=0.712). Conclusion : Serum leptin level in type I DM strongly correlated with the body fat percent. Despite lowered body fat percent in type I DM, the leptin level was significantly higher than values in healthy children. The mean leptin level in type I DM were significantly higher than value in healthy children, but body fat percent of type I DM was lower than value in healthy children who were adjusted for sex, age and body mass index. (J Korean Pediatr Soc 1999;43: 550-555)" @default.
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• W1180609160 date "2000-04-15" @default.
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• W1180609160 title "Serum Leptin Levels in Children with Type I Diabetes Mellitus" @default.
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