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- W118104596 abstract "Reduced renal function increases cardiovascular (CV) morbidity and mortality. We have reported that mild reduction in renal function produced by unilateral nephrectomy (UNX) increases myocardial collagen content resulting in myocardial diastolic impairment in the absence of hypertension. Natriuretic peptides (NPs) possess cardiorenal protective properties via activation of particulate guanylyl cyclase (GC) receptors. We hypothesized that in this model of mild renal dysfunction, that a novel Mayo designed chimeric NP, CD-NP, would prevent cardiac remodeling, diastolic impairment, suppress aldosterone (Aldo) and preserve renal function. CD-NP represents the first dual GC receptor agonist which has anti-fibrotic via GC-B, aldosterone suppressing and renopreserving properties via GC-A without excessive hypotension. Methods: Cardiorenal function and structure were assessed in Wistar rats (UNX;n=9) and (CD-NP UNX;n=9) 4 weeks (wk) after UNX. At wk 4 GFR, Na, water excretion, and Aldo were assessed. LV mass, EF,..." @default.
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- W118104596 date "2010-11-23" @default.
- W118104596 modified "2023-09-24" @default.
- W118104596 title "Abstract 20240: CD-NP, a Novel Dual Guanylyl Cyclase Receptor Activator, Decreases Fibrosis and Improves Diastolic Dysfunction Produced by Mild Renal Insufficiency" @default.
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