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- W118199183 abstract "S INCE THE DISCOVERY of the actomyosin-like contractile protein, thrombosthenin, a vast new area of research has been introduced in the study of platelets.�2 It has been suggested that this protein may, in some manner, be involved in platelet aggregation and/or clot retraction.36 An evaluation and comparison of the properties of contractile proteins with the reactions and factors involved in platelet aggregation suggested to us that platelet aggregation may be mediated by a surface or near surface localized actomyosin-like protein. The purpose of this communication is to propose a hypothetical molecular model for platelet aggregation, directly involving the participation of a surface or near surface localized actomyosin-like protein. The purpose of this communication is to propose a hypothetical molecular model for platelet aggregation, directly involving the participation of a surface or near surface localized actomyosin-like protein. An actomyosin-like protein ( thrombosthenin ) with typical contractile protein properties has been isolated from platelets.’2 This protein exhibits ATPase activity, consists of myosin-like and actin-like moieties,1’7 and constitutes 1520 per cent of the total platelet protein.�2 In addition, several investigators have presented data which may be interpreted as suggesting the surface or near surface location of at least part of this actomyosin-like protein. Nachman et al. have isolated thrombosthenin from purified platelet membranes;8 kinetic studies of Chambers et al. have indicated that the properties of the ectoATPase of intact platelets and those of isolated thrombosthenin are very similar, if not identical;9 thrombosthenin antiserum inhibited platelet ectoATPase activity and also induced platelet agglutination,10 suggesting the formation of a surface localized antigen-antibody complex, and finally the surface location indicated by the thrombosthenin-fluorescent antibody technic.8" @default.
- W118199183 created "2016-06-24" @default.
- W118199183 creator A5056779487 @default.
- W118199183 date "2016-01-01" @default.
- W118199183 modified "2023-09-27" @default.
- W118199183 title "Studies on Human Platelets III. A Contractile" @default.
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