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• W118242804 endingPage "92" @default.
• W118242804 startingPage "37" @default.
• W118242804 abstract "The enormous range of drugs which have recently become available for the treatment of the 100 or so different arthritic conditions present the physician with a challenge to determine if there are some of these which are more suitable than others. Inspection of Table 1 indicates that of over 100 or so nonsteroidal anti-inflammatory drugs (NSAIDs) these can be graded in terms of overall potency to be roughly equivalent to one of the four ‘traditional’ or well-established drugs, i.e. aspirin, ibuprofen, indomethacin and phenylbutazone. It could therefore, be argued that it is pointless having many of the new NSAIDs since these may be no better than those which are well established? This challenging question receives further provocate support from several well-established tenets frequently uttered by clinicians and even experts alike that (a) NSAIDs act by inhibiting the synthesis of inflammatory prostaglandins (PGs) (b) the anti-inflammatory and analgesic efficacy of these drugs is directly related to their inhibitory effects as PG synthesis inhibitors, and (c) with some few exceptions their potency as anti-inflammatory agents is correlated with their propensity to produce side-effects especially in the gastrointestinal tract1–3. Even the term ‘Aspirin-like’2 as frequently and, probably inappropriately, misapplied to all NSAIDs, conjures up in the mind the notion that all NSAIDs are the same, but possibly differ in potency only. If these features constitute the basis for the actions of the NSAIDs overall then it can be logically argued why do we really need all the drugs that we have, except for the few cases they have proven unacceptably toxic." @default.
• W118242804 created "2016-06-24" @default.
• W118242804 creator A5044578278 @default.
• W118242804 date "1989-01-01" @default.
• W118242804 modified "2023-10-16" @default.
• W118242804 title "Concepts of the mode of action and toxicity of anti-inflammatory drugs. A basis for safer and more selective therapy, and for future drug developments" @default.
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