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- W1183711306 abstract "Publisher Summary This chapter discusses the regulation of phosphoinositide metabolism in membranes prepared from human brain cortex. The phosphoinositide signaling pathway is a major mechanism through which neurotransmitters affect intracellular calcium and diacylglycerol levels, thus playing an important role in neuronal function. Activation of phosphoinositide-specific phospholipase C (PI–PLC) through guanine nucleotide-binding (G) proteins is the proven or suspected pathway of transmembrane signaling. Hydrolysis of the phosphoinositides by PI–PLC is promoted by a variety of neurotransmitters in a guanine nucleotide-dependent manner. In conclusion with the exogenous substrate assay for PI–PLC activation, it is possible to get functional data from autopsied human tissue concerning the coupling of neurotransmitter receptors to G proteins and then to PI–PLC. In these assays, the PI in membranes is labeled with [ 3 H] inositol through the reverse reaction of PI synthase, and this PI is subsequently converted to PI (4) P and PIP 2 by the appropriate kinase activities in the presence of ATP. Finally, the newly made [ 3 H] PIP and [ 3 H] PIP 2 are degraded by PI–PLC when stimulated by GTPγS and carbachol." @default.
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- W1183711306 date "1993-01-01" @default.
- W1183711306 modified "2023-09-24" @default.
- W1183711306 title "Regulation of Phosphoinositide Metabolism in Membranes Prepared from Human Brain Cortex" @default.
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- W1183711306 doi "https://doi.org/10.1016/b978-0-12-185285-6.50012-9" @default.
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