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• W1183946645 abstract "We report novel anti-HIV-1 agents with combined dual host–pathogen pharmacology. Lead compound 3, composed of a pyrazole-piperidine core, exhibits three concurrent mechanisms of action: (1) non-nucleoside reverse transcriptase inhibition, (2) CCR5-mediated M-tropic viral entry inhibition, and (3) CXCR4-based T-tropic viral entry inhibition that maintains native chemokine ligand binding. This discovery identifies important tool compounds for studying viral infectivity and prototype agents that block HIV-1 entry through dual chemokine receptor ligation." @default.
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• W1183946645 date "2015-06-08" @default.
• W1183946645 modified "2023-10-03" @default.
• W1183946645 title "Pyrazolo-Piperidines Exhibit Dual Inhibition of CCR5/CXCR4 HIV Entry and Reverse Transcriptase" @default.
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• W1183946645 doi "https://doi.org/10.1021/acsmedchemlett.5b00036" @default.
• W1183946645 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4499816" @default.
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