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- W1184837095 abstract "Publisher SummaryThis chapter provides an overview of pathogenetic role and methods of detection of myelin basic protein (MBP) autoantibodies or anti-MBP antibodies, which is a major protein component of central nervous system myelin. MBP was identified as the antigen causing experimental allergic encephalomyelitis and much research has focused on its possible pathogenic role as a target for the immune attack in multiple sclerosis (MS). Elevated anti-MBP titers were subsequently observed in the cerebrospinal fluid of a majority of patients experiencing first relapses of MS as well as in most patients with first attacks of optic neuritis. The most commonly used methods for detecting anti- MBP are solid-phase radio immuno assay and enzyme-linked immunosorbent assay. Autoantibodies to MBP are also found in various neurological disorders associated with demyelination. Anti-MBP are potentially useful markers in assessing the disease activity and the progression of demyelinating diseases." @default.
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- W1184837095 date "1996-01-01" @default.
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- W1184837095 title "Myelin Basic Protein Autoantibodies" @default.
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- W1184837095 doi "https://doi.org/10.1016/b978-044482383-0/50080-7" @default.
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