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- W118492017 abstract "Despite the importance of drug resistance, both intrinsic and acquired following chemotherapy, relatively little is known of the mechanisms underlying resistance to chemotherapeutic agents in the clinic [1]. This lack of information is a result of the inherent difficulties in studying tumors from patients. Inadequate samples, tumor heterogeneity, and inability to obtain repetitive biopsies are some reasons for this paucity of information relative to the large amount of data regarding mechanisms of resistance to these drugs both at the phenotypic as well as the genetic level in experimental tumors.KeywordsBlast CellDihydrofolate ReductaseDHFR GeneDihydrofolate Reductase GeneDHFR ActivityThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
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- W118492017 date "1992-01-01" @default.
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- W118492017 title "Development of Sensitive Assays to Detect Antifolate Resistance in Leukemia Blasts" @default.
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- W118492017 doi "https://doi.org/10.1007/978-3-642-76591-9_3" @default.
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