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- W118537065 abstract "This chapter focuses on nonesterified fatty acids (NEFAs), the risk factor cluster, and vascular pathophysiology. The discussion begins with an overview of the cluster and the possible pathogenetic link to the defect of insulin-mediated glucose disposal. Selected controversies in the insulin resistance—hypertension theory are addressed and another defect of insulin action, namely suppression of lipolysis and plasma NEFAs, is offered as an alternative explanation linking insulin resistance to hypertension. The emphasis moves to mechanisms by which NEFAs may modulate vascular function and structure with a focus on neurovascular tone and endothelium-dependent vasodilation. The chapter closes with thoughts on the implications of increased plasma NEFAs and their effects on neurovascular tone and endothelium-dependent vasodilation to the pathophysiology in the diabetic hypertensive." @default.
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- W118537065 date "1996-01-01" @default.
- W118537065 modified "2023-10-17" @default.
- W118537065 title "Evidence Linking Fatty Fat Acids, the Risk Factor Cluster, and Vascular Pathophysiology" @default.
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- W118537065 doi "https://doi.org/10.1007/978-1-4612-0231-8_12" @default.
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