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- W1185686039 endingPage "9479" @default.
- W1185686039 startingPage "9451" @default.
- W1185686039 abstract "Because of the minimal and clearly insufficient ability of the adult heart to regenerate after ischemic injury, there is a great opportunity to identify biological mechanisms, substances, and factors that enhance this process. Hence, innovative therapeutic management of heart failure following infarction requires a paradigm shift in pharmacotherapy. Spurred by tremendous progress in the field of stem cell and cardiac biology, several attractive approaches for regeneration of lost cardiomyocytes and supporting vasculature have emerged. Research in this area focuses on restoring the hearts’ original function via proliferation and differentiation of cardiac progenitor cells, proliferation of pre-existing cardiomyocytes, and reprogramming of cardiac fibroblasts. In this review, we outline these principal strategies, putative biological targets or signaling pathways and chemical agents, with a focus on small molecules, to achieve therapeutic heart regeneration. We also point out the many remaining questions and challenges, particularly for translating in vitro discoveries to in vivo application." @default.
- W1185686039 created "2016-06-24" @default.
- W1185686039 creator A5007493361 @default.
- W1185686039 creator A5031965516 @default.
- W1185686039 date "2015-09-03" @default.
- W1185686039 modified "2023-09-23" @default.
- W1185686039 title "Medicinal Chemistry Approaches to Heart Regeneration" @default.
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