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• W11863419 endingPage "189" @default.
• W11863419 startingPage "181" @default.
• W11863419 abstract "This work reports on the synthesis, characterization and biological activity of new coordination compounds of the type [M(TSDTM)X2] (M=Pt(II), Pd(II); X=Cl, Br; TSDTM=ter-butylsarcosine(S-methyl)dithiocarbamate) and [Pd(TSDT)X]n (TSDT=ter-butylsarcosinedithiocarbamate) in order to study their behavior as potential antitumor agents. All the synthesized compounds were characterized by means of elemental analysis, FT-IR, 1H and 13C-NMR spectroscopy and thermogravimetric analysis, suggesting a chelate S,S′ structure of the TSDTM/TSDT ligand in a square-planar geometry. Finally, the synthesized complexes have been tested for in vitro cytotoxic activity against human leukemic HL60 and adenocarcinoma HeLa cells; the most active compound [Pt(TSDTM)Br2], characterized by IC50 values very similar to those of the reference compound (cisplatin), was also tested for in vitro nephrotoxicity showing a very low renal cytotoxicity as compared to cisplatin itself." @default.
• W11863419 created "2016-06-24" @default.
• W11863419 creator A5000651210 @default.
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• W11863419 date "2003-01-01" @default.
• W11863419 modified "2023-09-30" @default.
• W11863419 title "Pt(II) and Pd(II) derivatives of ter-butylsarcosinedithiocarbamate" @default.
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• W11863419 doi "https://doi.org/10.1016/s0162-0134(02)00571-8" @default.
• W11863419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12576280" @default.
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