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- W1188871022 abstract "Publisher Summary The method for lowering tissue glutathione (GSH) levels involves the administration of compounds that react enzymically with GSH to form conjugates. The inhibition of GSH synthesis can also result in the depletion of this tripeptide in the organs with a sufficient turnover rate. The conversion of GSH to its oxidized form, glutathione disulfide (GSSG), has also been used to deplete GSH, mainly in isolated cell preparations; the choice of the depleting agent depends on the type of system under study. Diethyl maleate (DEM) remains one of the most useful compounds for depleting hepatic GSH in vivo. Intraperitoneal administration of DEM reduces the hepatic GSH levels of rats to 6-20% of control values in 30 min and for a period of 2 to 4 hr. Phorone is another α,β-unsaturated carbonyl compound that may be useful as a GSH depleting agent. As in the case of DEM, the conjugation of phorone with GSH is catalyzed by glutathione transferases." @default.
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- W1188871022 date "1981-01-01" @default.
- W1188871022 modified "2023-10-16" @default.
- W1188871022 title "[8] Chemical depletion of glutathione in vivo" @default.
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- W1188871022 doi "https://doi.org/10.1016/s0076-6879(81)77010-1" @default.
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