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- W1189115579 abstract "Objective:To investigate the effects of sodium phenylbutyrate(NaPB) on the matrix metalloproteinase-9(MMP-9) and tissue inhibitor of metalloproteinase-1(TIMP-1) expression and invasive ability of human thyroid follicular carcinoma cell line CGTHW-1.Methods: CGTHW-1 cells were treated with different concentrations of NaPB,then the invasive ability of CGTHW-1 cells was assessed using Transwell assay.The expression of MMP-9 and TIMP-1 was examined by immunocytochemistry staining and RT-PCR in CGTHW-1 cells.Results: After treatment with NaPB(4 mmol/L) for 72 h,CGTHW-1 cells passing the Transwell were significantly reduced[(29.8±1.77) vs(11.00±2.59),P0.05].Immunocytochemistry staining and RT-PCR demonstrated that protein and mRNA expression of MMP-9 and TIMP-1 were significantly down-regulated in CGTHW-1 cells after NaPB treatment(4,6 mmol/L)(all P0.05).Conclusion: NaPB can inhibit CGTHW-1 cell invasion by down-regulating MMP-9 and TIMP-1 expression." @default.
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- W1189115579 date "2009-01-01" @default.
- W1189115579 modified "2023-09-28" @default.
- W1189115579 title "Effects of sodium phenylbutyrate on invasive ability of human thyroid follicular carcinoma cell line and expression of MMP-9 and TIMP-1." @default.
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