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- W1189408096 abstract "The speciation of the potential antitumor agent vanadocene dichloride ([Cp2VCl2], abbreviated with VDC) in the blood plasma was studied by instrumental (EPR, ESI-MS, MS-MS, and electronic absorption spectroscopy) and computational (DFT) methods. The behavior of VDC at pH 7.4 in aqueous solution, the interaction with the most important bioligands of the plasma (oxalate, carbonate, phosphate, lactate, citrate, histidine, and glycine among those with low molecular mass and transferrin and albumin between the proteins) was evaluated. The results suggest that [Cp2VCl2] transforms at physiological pH to [Cp2V(OH)2] and that only oxalate, carbonate, phosphate, and lactate are able to displace the two OH(-) ions to yield [Cp2V(ox)], [Cp2V(CO3)], [Cp2V(lactH(-1))], and [Cp2V(HPO4)]. The formation of the adducts with oxalate, carbonate, lactate, and hydrogen phosphate was confirmed also by ESI-MS and MS-MS spectra. The stability order is [Cp2V(ox)] ≫ [Cp2V(CO3)] > [Cp2V(lactH(-1))] > [Cp2V(HPO4)]. No interaction between VDC and plasma proteins was detected under our experimental conditions. Several model systems containing the bioligands (bL) in the same relative ratio as in the blood samples were also examined. Finally, the speciation of VDC in the plasma was studied. The results obtained show that the model systems behave as the blood plasma and indicate that when V concentration is low (10 μM) VDC is transported in the bloodstream as [Cp2V(ox)]; when V concentration is high (100 μM) oxalate binds only 9.2 μM of [Cp2V](2+), whereas the remaining part distributes between [Cp2V(CO3)] (main species) and [Cp2V(lactH(-1))] (minor species); and when V concentration is in the range 10-100 μM [Cp2V](2+) distributes between [Cp2V(ox)] and [Cp2V(CO3)]." @default.
- W1189408096 created "2016-06-24" @default.
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- W1189408096 date "2015-08-17" @default.
- W1189408096 modified "2023-10-17" @default.
- W1189408096 title "Speciation of the Potential Antitumor Agent Vanadocene Dichloride in the Blood Plasma and Model Systems" @default.
- W1189408096 cites W1889306204 @default.
- W1189408096 cites W1963497136 @default.
- W1189408096 cites W1963818903 @default.
- W1189408096 cites W1967743782 @default.
- W1189408096 cites W1972004058 @default.
- W1189408096 cites W1973591492 @default.
- W1189408096 cites W1974794668 @default.
- W1189408096 cites W1975289475 @default.
- W1189408096 cites W1980068824 @default.
- W1189408096 cites W1981066719 @default.
- W1189408096 cites W1981172977 @default.
- W1189408096 cites W1983792038 @default.
- W1189408096 cites W1984046857 @default.
- W1189408096 cites W1984458851 @default.
- W1189408096 cites W1985030518 @default.
- W1189408096 cites W1987553535 @default.
- W1189408096 cites W1989455167 @default.
- W1189408096 cites W1989475263 @default.
- W1189408096 cites W1990189138 @default.
- W1189408096 cites W1991733323 @default.
- W1189408096 cites W1994221242 @default.
- W1189408096 cites W1996085765 @default.
- W1189408096 cites W2000542480 @default.
- W1189408096 cites W2002046159 @default.
- W1189408096 cites W2002642272 @default.
- W1189408096 cites W2006481826 @default.
- W1189408096 cites W2009920562 @default.
- W1189408096 cites W2010869945 @default.
- W1189408096 cites W2013112527 @default.
- W1189408096 cites W2015694743 @default.
- W1189408096 cites W2017015180 @default.
- W1189408096 cites W2019537079 @default.
- W1189408096 cites W2020732409 @default.
- W1189408096 cites W2020962599 @default.
- W1189408096 cites W2021036518 @default.
- W1189408096 cites W2030281139 @default.
- W1189408096 cites W2032031144 @default.
- W1189408096 cites W2036617397 @default.
- W1189408096 cites W2039603556 @default.
- W1189408096 cites W2041363678 @default.
- W1189408096 cites W2042154597 @default.
- W1189408096 cites W2042280980 @default.
- W1189408096 cites W2043025602 @default.
- W1189408096 cites W2043123654 @default.
- W1189408096 cites W2045329548 @default.
- W1189408096 cites W2046770888 @default.
- W1189408096 cites W2047584461 @default.
- W1189408096 cites W2050545246 @default.
- W1189408096 cites W2050998105 @default.
- W1189408096 cites W2051317194 @default.
- W1189408096 cites W2051352510 @default.
- W1189408096 cites W2051516572 @default.
- W1189408096 cites W2053270277 @default.
- W1189408096 cites W2056083348 @default.
- W1189408096 cites W2056265661 @default.
- W1189408096 cites W2058895198 @default.
- W1189408096 cites W2060663852 @default.
- W1189408096 cites W2062675702 @default.
- W1189408096 cites W2063575643 @default.
- W1189408096 cites W2064899900 @default.
- W1189408096 cites W2065083690 @default.
- W1189408096 cites W2065614201 @default.
- W1189408096 cites W2065894789 @default.
- W1189408096 cites W2066305618 @default.
- W1189408096 cites W2067718414 @default.
- W1189408096 cites W2068193883 @default.
- W1189408096 cites W2070247876 @default.
- W1189408096 cites W2073706866 @default.
- W1189408096 cites W2076316855 @default.
- W1189408096 cites W2076632818 @default.
- W1189408096 cites W2078429789 @default.
- W1189408096 cites W2079256203 @default.
- W1189408096 cites W2080175747 @default.
- W1189408096 cites W2080786846 @default.
- W1189408096 cites W2081220317 @default.
- W1189408096 cites W2083526260 @default.
- W1189408096 cites W2084458832 @default.
- W1189408096 cites W2086699102 @default.
- W1189408096 cites W2086997985 @default.
- W1189408096 cites W2088470845 @default.
- W1189408096 cites W2091128902 @default.
- W1189408096 cites W2091380301 @default.
- W1189408096 cites W2093535449 @default.
- W1189408096 cites W2094971466 @default.
- W1189408096 cites W2102816639 @default.
- W1189408096 cites W2102938402 @default.
- W1189408096 cites W2103302128 @default.