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• W118947172 abstract "Prostate-specific antigen (PSA) is one of the most widely applied screening tests in current medical practice. Its widespread use has had a tremendous impact on all aspects of the management of prostate cancer. PSA screening has led to a stage migration to more organ-confined cancers at the time of diagnosis and is temporally associated with a decrease in prostate cancer mortality. However, PSA screening is imperfect and remains controversial. In this chapter we review the history of the discovery, initial studies, and subsequent widespread application of PSA screening. Initial studies were limited by the lack of applicability to all ethnic groups, upper limits of normal determined with incomplete ascertainment of disease status among study participants, and obsolete biopsy techniques. Various modifications of PSA-based screening have been adopted clinically without sufficient validation. More recent studies have elucidated the non-dichotomous nature of PSA as well as the contribution of other factors to the overall risk for prostate cancer. We await the results of large-scale clinical trials that will more clearly define the impact of PSA screening on prostate cancer mortality as well as the discovery and validation of additional prognostic biomarkers." @default.
• W118947172 created "2016-06-24" @default.
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• W118947172 date "2009-01-01" @default.
• W118947172 modified "2023-09-24" @default.
• W118947172 title "Evolution of Prostate-Specific Antigen for Screening" @default.
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• W118947172 doi "https://doi.org/10.1007/978-1-60327-281-0_5" @default.
• W118947172 hasPublicationYear "2009" @default.
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