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- W118960006 abstract "SummaryCGP 28 014 A is a specific inhibitor of catechol-O-methyl transferase (COMT). The effect on COMT was assessed with the levodopa test in 5 unmedicated subjects and after pretreatment with 200–600 mg CGP 28 014 p.o. Plasma concentrations of DOPA, 3-O-methyldopa (3OD), 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid were measured. CGP 28 014 A decreased 3OMD not dose-related by 67% (p < 0.05). This, and an increase of DOPAC shows COMT inhibition by this compound in humans." @default.
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- W118960006 date "1990-01-01" @default.
- W118960006 modified "2023-09-27" @default.
- W118960006 title "Effect of the new selective COMT inhibitor CGP 28014 A on the formation of 3-O-methyldopa (3OMD) in plasma of healthy subjects" @default.
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- W118960006 doi "https://doi.org/10.1007/978-3-7091-9113-2_53" @default.
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