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• W118974209 abstract "The overall goal of this chapter is to provide an overview of the complement system, its involvement in various pathophysiological conditions, and its interventions by inhibitors. The first area is the biochemistry of the complement initiation process and the molecular mechanisms that govern its activation. The second is an understanding of the mechanisms by which complement immunoregulatory and proinflammatory activities are propagated at the cellular level through specific receptor and signaling pathways. The third issue, is to review the data that implicate complementactivation as a pathogenic, disease-promoting effector mechanism in clinically important human diseases. The fourth area involves the question of how to deliver complement inhibitors and whether to attempt to target their activities to local tissue sites. Finally, issues relative to the potential side effects of diminishing protective complement activities through the use of inhibitory therapeutics are discussed." @default.
• W118974209 created "2016-06-24" @default.
• W118974209 creator A5040063597 @default.
• W118974209 date "2000-01-01" @default.
• W118974209 modified "2023-09-23" @default.
• W118974209 title "Complement as a Regulatory and Effector Pathway in Human Diseases" @default.
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• W118974209 doi "https://doi.org/10.1007/978-1-59259-017-9_1" @default.
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