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• W118996963 abstract "Anatomists suggested many years ago that inhibitory interactions among the spiny projection neurons of the striatum are very probable and might give rise to a lateral inhibition type of neural network. Inhibitory interactions have since been confirmed by direct electrophysiological measurement using dual intracellular or whole cell recordings from pairs of spiny projection neurons. Inhibitory interactions have the potential to produce competitive dynamics among spiny projection neurons, though the importance of this role is debated because lateral inhibition is sparse and weak at the level of individual synaptic connections. On the other hand, at the population level, network simulations using realistic values for synaptic connectivity and efficacy support the concept of the striatum as a dynamic focussing device based on lateral inhibition. This operation may be important for normal function of the striatum in the selection of motor programs. Previously, it has been shown that neuromodulators, such as dopamine, modulate lateral inhibition in the striatum. In Parkinson’s disease, loss of dopaminergic modulation of lateral inhibition may alter striatal dynamics and contribute to some of the symptoms of Parkinson’s disease. Therefore, modulators that restore striatal dynamics may have therapeutic potential. Recently, we have shown that adenosine A2A receptors increase lateral inhibition in the striatum, an effect mediated by presynaptic modulation of spiny neuron terminals. These receptors are of particular interest in view of the therapeutic effects of adenosine A2A receptor antagonists in Parkinson’s disease. Here we summarise our current thinking about lateral inhibition in the striatum, its modulation by adenosine A2A receptors, and its significance for the therapeutic effects of A2A receptor antagonists in Parkinson’s disease." @default.
• W118996963 created "2016-06-24" @default.
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• W118996963 date "2008-12-31" @default.
• W118996963 modified "2023-09-26" @default.
• W118996963 title "Neuromodulation and Neurodynamics of Striatal Inhibitory Networks: Implications for Parkinson’s Disease" @default.
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• W118996963 doi "https://doi.org/10.1007/978-1-60327-252-0_14" @default.
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