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- W119015983 endingPage "144" @default.
- W119015983 startingPage "113" @default.
- W119015983 abstract "Cell division involves a series of ordered and controlled events that lead to cell proliferation. Cell cycle progression implies not only demanding amounts of cell mass, protein, lipid, and nucleic acid content but also a favorable energy state. The mammalian target of rapamycin (mTOR), in response to the energy state, nutrient status, and growth factor stimulation of cells, plays a pivotal role in the coordination of cell growth and the cell cycle. Here, we review how the nutrient-sensing mTOR-signaling cascade molecularly integrates nutritional and mitogenic/anti-apoptotic cues to accurately coordinate cell growth and cell cycle. First, we briefly outline the structure, functions, and regulation of the mTOR complexes (mTORC1 and mTORC2). Second, we concisely evaluate the best known ability of mTOR to control G1-phase progression. Third, we discuss in detail the recent evidence that indicates a new genome stability caretaker function of mTOR based on the specific ability of phosphorylated forms of several mTOR-signaling components (AMPK, raptor, TSC, mTOR, and S6K1), which spatially and temporally associate with essential mitotic regulators at the mitotic spindle and at the cytokinetic cleavage furrow." @default.
- W119015983 created "2016-06-24" @default.
- W119015983 creator A5002132146 @default.
- W119015983 creator A5045599657 @default.
- W119015983 creator A5053780005 @default.
- W119015983 creator A5060700554 @default.
- W119015983 date "2014-01-01" @default.
- W119015983 modified "2023-10-06" @default.
- W119015983 title "Cell Cycle Regulation by the Nutrient-Sensing Mammalian Target of Rapamycin (mTOR) Pathway" @default.
- W119015983 cites W1589421810 @default.
- W119015983 cites W1918384196 @default.
- W119015983 cites W1968092563 @default.
- W119015983 cites W1969236463 @default.
- W119015983 cites W1969319225 @default.
- W119015983 cites W1972618720 @default.
- W119015983 cites W1980439394 @default.
- W119015983 cites W1980848382 @default.
- W119015983 cites W1981557521 @default.
- W119015983 cites W1982219839 @default.
- W119015983 cites W1983698019 @default.
- W119015983 cites W1985754630 @default.
- W119015983 cites W1986301677 @default.
- W119015983 cites W1990098395 @default.
- W119015983 cites W1990686151 @default.
- W119015983 cites W1992170852 @default.
- W119015983 cites W1995231689 @default.
- W119015983 cites W1998682097 @default.
- W119015983 cites W1998884444 @default.
- W119015983 cites W1999330214 @default.
- W119015983 cites W2000731858 @default.
- W119015983 cites W2001568034 @default.
- W119015983 cites W2002226709 @default.
- W119015983 cites W2002636911 @default.
- W119015983 cites W2003023964 @default.
- W119015983 cites W2004582874 @default.
- W119015983 cites W2004768888 @default.
- W119015983 cites W2005892444 @default.
- W119015983 cites W2006559495 @default.
- W119015983 cites W2008862544 @default.
- W119015983 cites W2011282245 @default.
- W119015983 cites W2014179668 @default.
- W119015983 cites W2015222879 @default.
- W119015983 cites W2015793629 @default.
- W119015983 cites W2016752484 @default.
- W119015983 cites W2016869069 @default.
- W119015983 cites W2018373960 @default.
- W119015983 cites W2018553282 @default.
- W119015983 cites W2020700496 @default.
- W119015983 cites W2022630818 @default.
- W119015983 cites W2022984399 @default.
- W119015983 cites W2023012828 @default.
- W119015983 cites W2024196905 @default.
- W119015983 cites W2025176940 @default.
- W119015983 cites W2025582729 @default.
- W119015983 cites W2026681127 @default.
- W119015983 cites W2027785297 @default.
- W119015983 cites W2032535383 @default.
- W119015983 cites W2032685334 @default.
- W119015983 cites W2034210044 @default.
- W119015983 cites W2034605152 @default.
- W119015983 cites W2035031849 @default.
- W119015983 cites W2035188342 @default.
- W119015983 cites W2035568149 @default.
- W119015983 cites W2037572151 @default.
- W119015983 cites W2038874082 @default.
- W119015983 cites W2039494527 @default.
- W119015983 cites W2041811289 @default.
- W119015983 cites W2041855679 @default.
- W119015983 cites W2042283565 @default.
- W119015983 cites W2042461504 @default.
- W119015983 cites W2043092063 @default.
- W119015983 cites W2044502296 @default.
- W119015983 cites W2046024621 @default.
- W119015983 cites W2047904857 @default.
- W119015983 cites W2049748684 @default.
- W119015983 cites W2050036331 @default.
- W119015983 cites W2050696207 @default.
- W119015983 cites W2051648135 @default.
- W119015983 cites W2053934223 @default.
- W119015983 cites W2054998824 @default.
- W119015983 cites W2056040807 @default.
- W119015983 cites W2056137479 @default.
- W119015983 cites W2056664023 @default.
- W119015983 cites W2057106513 @default.
- W119015983 cites W2059765843 @default.
- W119015983 cites W2060905299 @default.
- W119015983 cites W2063013559 @default.
- W119015983 cites W2065080656 @default.
- W119015983 cites W2065322400 @default.
- W119015983 cites W2065887259 @default.
- W119015983 cites W2065906581 @default.
- W119015983 cites W2066659565 @default.
- W119015983 cites W2068159774 @default.
- W119015983 cites W2071131807 @default.
- W119015983 cites W2074782537 @default.
- W119015983 cites W2075277855 @default.
- W119015983 cites W2077453272 @default.
- W119015983 cites W2077551355 @default.