FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1190614130> ?p ?o ?g. }

• W1190614130 endingPage "202" @default.
• W1190614130 startingPage "189" @default.
• W1190614130 abstract "Gyrase was the first type II enzyme discovered, and it remains unique for its ability to introduce negative supercoils into relaxed, positively or negatively supercoiled DNA at the expense of ATP binding and hydrolysis. An essential enzyme in bacteria, gyrase is critical for nearly all complex transactions that involve DNA, including recombination, replication, transcription, and chromosome segregation. The homeostatic regulation model was inspired by two observations. First, many promoters sense supercoiling levels. Second, expression of gyrase increases when the chromosome becomes relaxed, whereas the expression of topo I requires high supercoiling levels. Chromosome replication has three critical stages (initiation, elongation, and segregation), each with different supercoiling problems. For initiation, the two strands of oriC must separate to allow assembly of the replication machinery (the replisome). Transcription encompasses supercoiling problems similar in two respects to those of replication. First, transcription initiation requires unpairing of the DNA duplex, and supercoiling can influence this step as it does in initiation of DNA replication. Second, transcription is similar to replication in that movement of RNA polymerase generates temporary positive supercoiling ahead of, and negative supercoiling behind, the DNA segment that is being transcribed. The torsional effects of transcription have been studied with supercoil-sensitive promoters by measuring the formation of Z-DNA and by monitoring the extrusion of cruciforms. Homologous and site-specific genetic recombination, adaptive mutation, supercoil regulated gene transcription, gene order on chromosomes, and plasmid-chromosome replication segregation are all phenomena that are likely to be influenced by DNA dynamics." @default.
• W1190614130 created "2016-06-24" @default.
• W1190614130 creator A5073765564 @default.
• W1190614130 date "2014-04-08" @default.
• W1190614130 modified "2023-09-26" @default.
• W1190614130 title "DNA Supercoiling and Its Consequences for Chromosome Structure and Function" @default.
• W1190614130 cites W1494993457 @default.
• W1190614130 cites W1517199797 @default.
• W1190614130 cites W1519749633 @default.
• W1190614130 cites W1535247105 @default.
• W1190614130 cites W1547353710 @default.
• W1190614130 cites W1588664883 @default.
• W1190614130 cites W1592890331 @default.
• W1190614130 cites W1598546208 @default.
• W1190614130 cites W1600362513 @default.
• W1190614130 cites W1676955378 @default.
• W1190614130 cites W171239877 @default.
• W1190614130 cites W1720245305 @default.
• W1190614130 cites W1782700290 @default.
• W1190614130 cites W1805737641 @default.
• W1190614130 cites W1858539678 @default.
• W1190614130 cites W1896379201 @default.
• W1190614130 cites W1910394702 @default.
• W1190614130 cites W1965885026 @default.
• W1190614130 cites W1966245842 @default.
• W1190614130 cites W1967560742 @default.
• W1190614130 cites W1969244409 @default.
• W1190614130 cites W1970210978 @default.
• W1190614130 cites W1972227366 @default.
• W1190614130 cites W1973079886 @default.
• W1190614130 cites W1974325040 @default.
• W1190614130 cites W1974470327 @default.
• W1190614130 cites W1977096167 @default.
• W1190614130 cites W1979700870 @default.
• W1190614130 cites W1981897803 @default.
• W1190614130 cites W1984107327 @default.
• W1190614130 cites W1984360565 @default.
• W1190614130 cites W1984388559 @default.
• W1190614130 cites W1984409688 @default.
• W1190614130 cites W1985345774 @default.
• W1190614130 cites W1988031018 @default.
• W1190614130 cites W1990449397 @default.
• W1190614130 cites W1992889417 @default.
• W1190614130 cites W1992973763 @default.
• W1190614130 cites W1993759853 @default.
• W1190614130 cites W1993971869 @default.
• W1190614130 cites W1999137852 @default.
• W1190614130 cites W1999951014 @default.
• W1190614130 cites W2000264179 @default.
• W1190614130 cites W2001764918 @default.
• W1190614130 cites W2001823184 @default.
• W1190614130 cites W2002486322 @default.
• W1190614130 cites W2003901808 @default.
• W1190614130 cites W2006539754 @default.
• W1190614130 cites W2007848866 @default.
• W1190614130 cites W2010709173 @default.
• W1190614130 cites W2012913836 @default.
• W1190614130 cites W2013263544 @default.
• W1190614130 cites W2013831032 @default.
• W1190614130 cites W2017689892 @default.
• W1190614130 cites W2020005908 @default.
• W1190614130 cites W2023364466 @default.
• W1190614130 cites W2023820135 @default.
• W1190614130 cites W2030313795 @default.
• W1190614130 cites W2032359606 @default.
• W1190614130 cites W2033104163 @default.
• W1190614130 cites W2037718894 @default.
• W1190614130 cites W2038652935 @default.
• W1190614130 cites W2039503019 @default.
• W1190614130 cites W2039716647 @default.
• W1190614130 cites W2040562669 @default.
• W1190614130 cites W2042895151 @default.
• W1190614130 cites W2045710759 @default.
• W1190614130 cites W2046850778 @default.
• W1190614130 cites W2047802710 @default.
• W1190614130 cites W2049639006 @default.
• W1190614130 cites W2049917392 @default.
• W1190614130 cites W2051110150 @default.
• W1190614130 cites W2051198903 @default.
• W1190614130 cites W2054197881 @default.
• W1190614130 cites W2056406408 @default.
• W1190614130 cites W2056793770 @default.
• W1190614130 cites W2056808424 @default.
• W1190614130 cites W2057203470 @default.
• W1190614130 cites W2058940094 @default.
• W1190614130 cites W2060295978 @default.
• W1190614130 cites W2060417297 @default.
• W1190614130 cites W2063083243 @default.
• W1190614130 cites W2064503172 @default.
• W1190614130 cites W2067332276 @default.
• W1190614130 cites W2068370729 @default.
• W1190614130 cites W2069398764 @default.
• W1190614130 cites W2077667025 @default.
• W1190614130 cites W2082065029 @default.
• W1190614130 cites W2082065074 @default.
• W1190614130 cites W2085655662 @default.
• W1190614130 cites W2086107380 @default.
• W1190614130 cites W2092793380 @default.

• next