Matches in SemOpenAlex for { <https://semopenalex.org/work/W119071470> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W119071470 endingPage "112" @default.
- W119071470 startingPage "99" @default.
- W119071470 abstract "The effect of dopamine on cyclic AMP levels in tissue slices of canine myocardium and kidney, and in chopped superior mesenteric arterial wall was investigated to identify dopamine receptors. Tissues were incubated in modified Krebs-Henseleit Ringer bicarbonate solution at 37 degrees C for 20 min with test drugs, after 20-min preincubation. In the presence of 3-isobutyl-1-methylxanthine (IBMX), dopamine and apomorphine caused dose-dependent increases in cyclic AMP levels in the myocardium, kidney and superior mesenteric artery. Phentolamine significantly intensified the cyclic AMP-increasing effect of dopamine in the superior mesenteric artery, but it did not influence the cyclic AMP increase caused by dopamine or apomorphine in the myocardium and kidney. Propranolol markedly blocked the effect of dopamine on cyclic AMP levels in all tissues studied. Haloperidol slightly inhibited the effect of dopamine and completely blocked the effect of apomorphine in the myocardium and kidney. These data suggest that dopamine increases cyclic AMP levels by activating predominantly beta-adrenergic receptors and partly dopamine receptors in the canine myocardium, kidney and superior mesenteric artery. The present results also suggest that dopamine acts not only on beta-adrenergic and dopamine receptors but also on alpha-adrenergic receptors in the superior mesenteric artery. Contrary to the activation of beta-adrenergic and dopamine receptors, the activation of alpha-adrenergic receptors resulted in a decrease in cyclic AMP levels in this tissue." @default.
- W119071470 created "2016-06-24" @default.
- W119071470 creator A5043339952 @default.
- W119071470 date "1982-04-01" @default.
- W119071470 modified "2023-09-23" @default.
- W119071470 title "Dopamine-induced cyclic AMP increase in canine myocardium, kidney and superior mesenteric artery." @default.
- W119071470 doi "https://doi.org/10.18926/amo/30679" @default.
- W119071470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6182759" @default.
- W119071470 hasPublicationYear "1982" @default.
- W119071470 type Work @default.
- W119071470 sameAs 119071470 @default.
- W119071470 citedByCount "1" @default.
- W119071470 crossrefType "journal-article" @default.
- W119071470 hasAuthorship W119071470A5043339952 @default.
- W119071470 hasConcept C120069818 @default.
- W119071470 hasConcept C126322002 @default.
- W119071470 hasConcept C134018914 @default.
- W119071470 hasConcept C137183658 @default.
- W119071470 hasConcept C170493617 @default.
- W119071470 hasConcept C185592680 @default.
- W119071470 hasConcept C2777525119 @default.
- W119071470 hasConcept C2778151854 @default.
- W119071470 hasConcept C2780091579 @default.
- W119071470 hasConcept C2780253649 @default.
- W119071470 hasConcept C40465926 @default.
- W119071470 hasConcept C513476851 @default.
- W119071470 hasConcept C71924100 @default.
- W119071470 hasConceptScore W119071470C120069818 @default.
- W119071470 hasConceptScore W119071470C126322002 @default.
- W119071470 hasConceptScore W119071470C134018914 @default.
- W119071470 hasConceptScore W119071470C137183658 @default.
- W119071470 hasConceptScore W119071470C170493617 @default.
- W119071470 hasConceptScore W119071470C185592680 @default.
- W119071470 hasConceptScore W119071470C2777525119 @default.
- W119071470 hasConceptScore W119071470C2778151854 @default.
- W119071470 hasConceptScore W119071470C2780091579 @default.
- W119071470 hasConceptScore W119071470C2780253649 @default.
- W119071470 hasConceptScore W119071470C40465926 @default.
- W119071470 hasConceptScore W119071470C513476851 @default.
- W119071470 hasConceptScore W119071470C71924100 @default.
- W119071470 hasIssue "2" @default.
- W119071470 hasLocation W1190714701 @default.
- W119071470 hasOpenAccess W119071470 @default.
- W119071470 hasPrimaryLocation W1190714701 @default.
- W119071470 hasRelatedWork W119071470 @default.
- W119071470 hasRelatedWork W1968732594 @default.
- W119071470 hasRelatedWork W1972217943 @default.
- W119071470 hasRelatedWork W1995416613 @default.
- W119071470 hasRelatedWork W2005311942 @default.
- W119071470 hasRelatedWork W2015087860 @default.
- W119071470 hasRelatedWork W2021120258 @default.
- W119071470 hasRelatedWork W2068187373 @default.
- W119071470 hasRelatedWork W2097351584 @default.
- W119071470 hasRelatedWork W2439619951 @default.
- W119071470 hasVolume "36" @default.
- W119071470 isParatext "false" @default.
- W119071470 isRetracted "false" @default.
- W119071470 magId "119071470" @default.
- W119071470 workType "article" @default.