FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W119100554> ?p ?o ?g. }

• W119100554 endingPage "590" @default.
• W119100554 startingPage "583" @default.
• W119100554 abstract "Metal ions fold DNA junctions into a compact conformation that confers protection of all thymine bases to modification by osmium tetroxide. In the absence of the cation the arms of the junction are fully extended in an approximately square-planar configuration. Group IIa cations are effective in achieving a folded conformation of the junction at 80-100 microM, and there is an excellent agreement between the ionic concentrations that fold the junctions as deduced from gel electrophoretic experiments, and those that prevent osmium tetroxide reaction at the junction. Hexamminecobalt(III) achieves full folding at 2 microM, while spermine and spermidine are effective at 25 microM. Some transition metal ions such as Ni(II) may replace the group IIA cations. Monovalent ions of group IA are only partially effective in folding the junctions. Very much higher concentrations are necessary, gel electrophoretic mobilities suggest that a less symmetrical conformation is adopted and thymine bases at the junction remain reactive to osmium tetroxide. Charge-charge interactions at the centre of the junction are structurally extremely important. Substitution of junction phosphate groups by uncharged methyl phosphonates severely perturbs the structure of the junction. If just two phosphates are substituted, diametrically facing across the junction, the structure always folds in order to place the electrically neutral phosphate on the exchanging strands. We suggest that folding of the junction into the stacked X-structure generates electronegative clefts that can selectively bind metal ions, depending on the chemistry, size and charge of the ion. Moreover, occupation of these cavities is essential for junction folding, in order to reduce electrostatic repulsion.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W119100554 created "2016-06-24" @default.
• W119100554 creator A5002692427 @default.
• W119100554 creator A5027631667 @default.
• W119100554 creator A5054572303 @default.
• W119100554 date "1990-02-01" @default.
• W119100554 modified "2023-10-15" @default.
• W119100554 title "The role of metal ions in the conformation of the four-way DNA junction." @default.
• W119100554 cites W1967292655 @default.
• W119100554 cites W1976637763 @default.
• W119100554 cites W1981790154 @default.
• W119100554 cites W1983946766 @default.
• W119100554 cites W1984286262 @default.
• W119100554 cites W1985910275 @default.
• W119100554 cites W1987682801 @default.
• W119100554 cites W1988875152 @default.
• W119100554 cites W1990933742 @default.
• W119100554 cites W1992302499 @default.
• W119100554 cites W1992383792 @default.
• W119100554 cites W1994272135 @default.
• W119100554 cites W1996940767 @default.
• W119100554 cites W2000861398 @default.
• W119100554 cites W2008075900 @default.
• W119100554 cites W2009076367 @default.
• W119100554 cites W2010951031 @default.
• W119100554 cites W2011000655 @default.
• W119100554 cites W2019855583 @default.
• W119100554 cites W2020378172 @default.
• W119100554 cites W2021333801 @default.
• W119100554 cites W2024772122 @default.
• W119100554 cites W2024957115 @default.
• W119100554 cites W2027820521 @default.
• W119100554 cites W2031053922 @default.
• W119100554 cites W2034250860 @default.
• W119100554 cites W2038390368 @default.
• W119100554 cites W2045060152 @default.
• W119100554 cites W2047546353 @default.
• W119100554 cites W2050560798 @default.
• W119100554 cites W2051058497 @default.
• W119100554 cites W2063496615 @default.
• W119100554 cites W2073263035 @default.
• W119100554 cites W2075202084 @default.
• W119100554 cites W2083301155 @default.
• W119100554 cites W2084599573 @default.
• W119100554 cites W2084965795 @default.
• W119100554 cites W2090962585 @default.
• W119100554 cites W2102834112 @default.
• W119100554 cites W2142450735 @default.
• W119100554 cites W2147003359 @default.
• W119100554 cites W2152819939 @default.
• W119100554 cites W2160393299 @default.
• W119100554 cites W47581708 @default.
• W119100554 doi "https://doi.org/10.1002/j.1460-2075.1990.tb08146.x" @default.
• W119100554 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/551705" @default.
• W119100554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2303044" @default.
• W119100554 hasPublicationYear "1990" @default.
• W119100554 type Work @default.
• W119100554 sameAs 119100554 @default.
• W119100554 citedByCount "191" @default.
• W119100554 countsByYear W1191005542012 @default.
• W119100554 countsByYear W1191005542013 @default.
• W119100554 countsByYear W1191005542014 @default.
• W119100554 countsByYear W1191005542015 @default.
• W119100554 countsByYear W1191005542016 @default.
• W119100554 countsByYear W1191005542017 @default.
• W119100554 countsByYear W1191005542018 @default.
• W119100554 countsByYear W1191005542019 @default.
• W119100554 countsByYear W1191005542020 @default.
• W119100554 countsByYear W1191005542021 @default.
• W119100554 countsByYear W1191005542022 @default.
• W119100554 countsByYear W1191005542023 @default.
• W119100554 crossrefType "journal-article" @default.
• W119100554 hasAuthorship W119100554A5002692427 @default.
• W119100554 hasAuthorship W119100554A5027631667 @default.
• W119100554 hasAuthorship W119100554A5054572303 @default.
• W119100554 hasBestOaLocation W1191005541 @default.
• W119100554 hasConcept C120665830 @default.
• W119100554 hasConcept C121332964 @default.
• W119100554 hasConcept C145148216 @default.
• W119100554 hasConcept C161790260 @default.
• W119100554 hasConcept C178790620 @default.
• W119100554 hasConcept C185592680 @default.
• W119100554 hasConcept C199164860 @default.
• W119100554 hasConcept C2182769 @default.
• W119100554 hasConcept C2776858809 @default.
• W119100554 hasConcept C2779424567 @default.
• W119100554 hasConcept C540285154 @default.
• W119100554 hasConcept C544153396 @default.
• W119100554 hasConcept C552990157 @default.
• W119100554 hasConcept C55493867 @default.
• W119100554 hasConcept C555196967 @default.
• W119100554 hasConcept C71240020 @default.
• W119100554 hasConcept C8010536 @default.
• W119100554 hasConcept C93877712 @default.
• W119100554 hasConceptScore W119100554C120665830 @default.
• W119100554 hasConceptScore W119100554C121332964 @default.
• W119100554 hasConceptScore W119100554C145148216 @default.
• W119100554 hasConceptScore W119100554C161790260 @default.

• next