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- W119146565 abstract "Cancer is a leading cause of death worldwide. Conventional chemotherapy has drawbacks ranging from limited effectiveness, chemoresistance, and treatment-related side-effects and damages to healthy tissues. The idea of drug targeting started to emerge as early as 1906. As outlined by Danhier et al., the challenge ahead is about how to find proper targets, to develop a drug that exploits the targets, and finally to design the proper delivery system (carrier) for the drug [1]. Cancer nanomedicine is the use of nano-sized entities (10–200 nm) to diagnose, prevent, or treat cancer. These entities can be loaded with chemotherapeutics, nucleic acids, radiosensitizers, diagnostic agents and/or probes. This chapter displays an updated review of several nano-carrier platforms, their common features, and applications, followed by a discussion of the major mechanisms by which nano-carriers are targeted to cancer cells. Finally it discusses barriers that hinder the applications of nanomedicine in cancer chemotherapy, and how the rational design of the nanomedicine may overcome these barriers." @default.
- W119146565 created "2016-06-24" @default.
- W119146565 creator A5012613337 @default.
- W119146565 creator A5087576156 @default.
- W119146565 date "2014-01-01" @default.
- W119146565 modified "2023-10-16" @default.
- W119146565 title "Nanomedicine: The Promise and Challenges in Cancer Chemotherapy" @default.
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