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- W11915656 abstract "Editor—The decision to analyse the relapses for mania and depression separately in Perry et al’s trial in patients with bipolar disorder is crucial.1 The reported power analysis was calculated for the overall (mania and depression) relapse rate, but no result is shown relating to the overall relapse rate. This raises the possibility that the decision to split the outcomes was taken later.The authors explain why the decision was taken: they considered that the experimental and control treatments differed qualitatively for mania and depression. But did the data in the study influence the decision to split the outcomes? If separate analysis of the two outcomes was specified in advance in the study protocol the authors’ conclusions are justified. If it was not then the distinction between the different effects on manic and depressive relapse rates becomes an interesting observation that merits further study. Could the timing of the separation of the outcomes be made clearer?" @default.
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- W11915656 date "1999-06-05" @default.
- W11915656 modified "2023-10-14" @default.
- W11915656 title "Teaching patients with bipolar disorder to identify early symptoms of relapse" @default.
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- W11915656 doi "https://doi.org/10.1136/bmj.318.7197.1557b" @default.
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