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• W1191710596 abstract "Tripartite motif protein 25 (TRIM25), mediates K63-linked polyubiquitination of Retinoic acid inducible gene I (RIG-I) that is crucial for downstream antiviral interferon signaling. Here, we demonstrate that TRIM25 is required for melanoma differentiation-associated gene 5 (MDA5) and MAVS mediated activation of NF-κB and interferon production. TRIM25 is required for the full activation of NF-κB at the downstream of MAVS, while it is not involved in IRF3 nuclear translocation. Mechanical studies showed that TRIM25 is involved in TRAF6-mediated NF-κB activation. These collectively indicate that TRIM25 plays an additional role in RIG-I/MDA5 signaling other than RIG-I ubiquitination via activation of NF-κB." @default.
• W1191710596 created "2016-06-24" @default.
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• W1191710596 date "2015-08-21" @default.
• W1191710596 modified "2023-10-17" @default.
• W1191710596 title "Regulation of MDA5-MAVS Antiviral Signaling Axis by TRIM25 through TRAF6-Mediated NF-κB Activation" @default.
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• W1191710596 doi "https://doi.org/10.14348/molcells.2015.0047" @default.
• W1191710596 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4588718" @default.
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