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- W119205109 abstract "In view of the high endogenous pool of taurine in thrombocytes, as well as data on radiosensitivity of SH groups, the link between these two parameters in the course of development of radiation sickness in rats was explored. This study was conducted on 400 male albino rats. Radiation was delivered from an RUM-17 unit at a dose rate of 42 R/min and a total radiation dose of 650 R. Exposure of rats to 650 R radiation leads to a significant decline, on the 1st-4th day, in taurine and protein SH groups in thrombocytes. On the 4th-7th day of radiation sickness, taurine content of blood platelets was almost one-seventh the level in cells of intact animals. There was also an intensive decline in number of thiol groups, and on the 12th day the level of nonprotein SH groups was one-half the base background and the level of protein SH groups constituted only 16% of the background. On the 21st day there was normalization of taurine, protein, and nonprotein SH group levels. The dynamics of taurine level in cells after irradiation indicate that postradiation thrombocytopenia is not associated with the expected marked loss of taurine, on the contrary, all of the cellsmore » remaining in the blood stream contain almost the same amount of this amino acid as all thrombocytes of intact animals. Thus, the thrombocytes of irradiated animals are only partially responsible for some postradiation hyperexcretion of taurine and, apparently, in spite of their high radiosensitivity, they retain stable systems that provide for a high level of taurine and SH groups in these cells. (ERB)« less" @default.
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- W119205109 date "1978-01-01" @default.
- W119205109 modified "2023-09-24" @default.
- W119205109 title "Taurine and sulfhydryl group content of irradiated rat thrombocytes. [X rays]" @default.
- W119205109 hasPublicationYear "1978" @default.
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