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- W119240342 abstract "We describe a general strategy for creating peptidic oligomers that have unnatural backbones but nevertheless adopt a conformation very similar to the α-helix. These oligomers contain both α- and β-amino acid residues (α/β-peptides). If the β content reaches 25-30% of the residue total, and the β residues are evenly distributed along the backbone, then substantial resistance to proteolytic degradation is often observed. These α/β-peptides can mimic the informational properties of α-helices involved in protein-protein recognition events, as documented in numerous crystal structures. Thus, these unnatural oligomers can be a source of antagonists of undesirable protein-protein interactions that are mediated by natural α-helices, or agonists of receptors for which the natural polypeptide ligands are α-helical. Successes include mimicry of BH3 domains found in proapoptotic proteins, which leads to ligands for antiapoptotic Bcl-2 family proteins, and mimicry of the gp41 CHR domain, which leads to inhibition of HIV infection in cell-based assays." @default.
- W119240342 created "2016-06-24" @default.
- W119240342 creator A5023192029 @default.
- W119240342 creator A5034683355 @default.
- W119240342 date "2013-01-01" @default.
- W119240342 modified "2023-09-30" @default.
- W119240342 title "α-Helix Mimicry with α/β-Peptides" @default.
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- W119240342 cites W1964277748 @default.
- W119240342 cites W1965028293 @default.
- W119240342 cites W1970552333 @default.
- W119240342 cites W1971339327 @default.
- W119240342 cites W1972000972 @default.
- W119240342 cites W1973603776 @default.
- W119240342 cites W1974710306 @default.
- W119240342 cites W1976261939 @default.
- W119240342 cites W1976952810 @default.
- W119240342 cites W1978924350 @default.
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- W119240342 cites W1990666092 @default.
- W119240342 cites W1992001226 @default.
- W119240342 cites W1995787642 @default.
- W119240342 cites W1996275832 @default.
- W119240342 cites W1997152791 @default.
- W119240342 cites W2003706433 @default.
- W119240342 cites W2005399184 @default.
- W119240342 cites W2005929034 @default.
- W119240342 cites W2010087060 @default.
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- W119240342 cites W2024935501 @default.
- W119240342 cites W2024947155 @default.
- W119240342 cites W2028530561 @default.
- W119240342 cites W2029624878 @default.
- W119240342 cites W2031937579 @default.
- W119240342 cites W2035000249 @default.
- W119240342 cites W2037498259 @default.
- W119240342 cites W2037780945 @default.
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- W119240342 cites W2067431105 @default.
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- W119240342 cites W2081277508 @default.
- W119240342 cites W2086382266 @default.
- W119240342 cites W2087043215 @default.
- W119240342 cites W2090909356 @default.
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- W119240342 cites W2143312620 @default.
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- W119240342 doi "https://doi.org/10.1016/b978-0-12-394292-0.00019-9" @default.
- W119240342 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3928965" @default.
- W119240342 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23422441" @default.
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