FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W119252893> ?p ?o ?g. }

• W119252893 endingPage "2368" @default.
• W119252893 startingPage "2363" @default.
• W119252893 abstract "Abstract The glycoprotein IIb-IIIa complex (GP IIb-IIIa) is a multifunctional transmembrane protein on platelets. Its most completely described function is as a fibrinogen receptor that mediates platelet aggregation, but it is also involved in clot retraction, signal transduction, calcium transport, and other events. However, the mechanisms that regulate the functions of GP IIb-IIIa during platelet activation are largely unknown. One possible mechanism is phosphorylation, since several other receptors are regulated by this process. We found that GP IIIa, but not GP IIb, was phosphorylated in 32P-labeled platelets, predominantly on threonine residues. Furthermore, GP IIIa phosphorylation increased four-fold in platelets activated with thrombin or phorbol 12-myristate 13-acetate, but not at all in platelets treated with prostacyclin, an inhibitor of platelet activation. The thrombin-induced increase in phosphorylation was inhibited by pretreating platelets with prostacyclin or with staurosporin, a specific protein kinase C inhibitor. Thus, there is an increase in the level or turnover of phosphate on GP IIIa during platelet activation, most likely involving protein kinase C. This phosphorylation may regulate some aspect(s) of GP IIb-IIIa function." @default.
• W119252893 created "2016-06-24" @default.
• W119252893 creator A5029725861 @default.
• W119252893 creator A5041270490 @default.
• W119252893 creator A5065656807 @default.
• W119252893 creator A5088500963 @default.
• W119252893 date "1990-06-15" @default.
• W119252893 modified "2023-10-14" @default.
• W119252893 title "Glycoprotein IIIa is phosphorylated in intact human platelets" @default.
• W119252893 cites W116786207 @default.
• W119252893 cites W1519152316 @default.
• W119252893 cites W1553962583 @default.
• W119252893 cites W1589699489 @default.
• W119252893 cites W1589866689 @default.
• W119252893 cites W1595133660 @default.
• W119252893 cites W1597634219 @default.
• W119252893 cites W1605961154 @default.
• W119252893 cites W1623233150 @default.
• W119252893 cites W1638222837 @default.
• W119252893 cites W1970793486 @default.
• W119252893 cites W1985174072 @default.
• W119252893 cites W1998321319 @default.
• W119252893 cites W2001578819 @default.
• W119252893 cites W2001692359 @default.
• W119252893 cites W2004592917 @default.
• W119252893 cites W2009967151 @default.
• W119252893 cites W2010711286 @default.
• W119252893 cites W2020381325 @default.
• W119252893 cites W2021403302 @default.
• W119252893 cites W2049311704 @default.
• W119252893 cites W2057052269 @default.
• W119252893 cites W2073225492 @default.
• W119252893 cites W2081376444 @default.
• W119252893 cites W2090842401 @default.
• W119252893 cites W2095185765 @default.
• W119252893 cites W2097908856 @default.
• W119252893 cites W2100837269 @default.
• W119252893 cites W2165207329 @default.
• W119252893 cites W2295565150 @default.
• W119252893 cites W2338896395 @default.
• W119252893 doi "https://doi.org/10.1182/blood.v75.12.2363.2363" @default.
• W119252893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2112411" @default.
• W119252893 hasPublicationYear "1990" @default.
• W119252893 type Work @default.
• W119252893 sameAs 119252893 @default.
• W119252893 citedByCount "71" @default.
• W119252893 countsByYear W1192528932012 @default.
• W119252893 countsByYear W1192528932013 @default.
• W119252893 countsByYear W1192528932018 @default.
• W119252893 countsByYear W1192528932019 @default.
• W119252893 countsByYear W1192528932022 @default.
• W119252893 crossrefType "journal-article" @default.
• W119252893 hasAuthorship W119252893A5029725861 @default.
• W119252893 hasAuthorship W119252893A5041270490 @default.
• W119252893 hasAuthorship W119252893A5065656807 @default.
• W119252893 hasAuthorship W119252893A5088500963 @default.
• W119252893 hasBestOaLocation W1192528931 @default.
• W119252893 hasConcept C104551158 @default.
• W119252893 hasConcept C11960822 @default.
• W119252893 hasConcept C184235292 @default.
• W119252893 hasConcept C185592680 @default.
• W119252893 hasConcept C195794163 @default.
• W119252893 hasConcept C203014093 @default.
• W119252893 hasConcept C26828662 @default.
• W119252893 hasConcept C2777292125 @default.
• W119252893 hasConcept C2778863912 @default.
• W119252893 hasConcept C2781128415 @default.
• W119252893 hasConcept C2910542480 @default.
• W119252893 hasConcept C3018697912 @default.
• W119252893 hasConcept C55493867 @default.
• W119252893 hasConcept C62478195 @default.
• W119252893 hasConcept C86803240 @default.
• W119252893 hasConcept C87325107 @default.
• W119252893 hasConcept C89560881 @default.
• W119252893 hasConcept C95444343 @default.
• W119252893 hasConcept C97029542 @default.
• W119252893 hasConceptScore W119252893C104551158 @default.
• W119252893 hasConceptScore W119252893C11960822 @default.
• W119252893 hasConceptScore W119252893C184235292 @default.
• W119252893 hasConceptScore W119252893C185592680 @default.
• W119252893 hasConceptScore W119252893C195794163 @default.
• W119252893 hasConceptScore W119252893C203014093 @default.
• W119252893 hasConceptScore W119252893C26828662 @default.
• W119252893 hasConceptScore W119252893C2777292125 @default.
• W119252893 hasConceptScore W119252893C2778863912 @default.
• W119252893 hasConceptScore W119252893C2781128415 @default.
• W119252893 hasConceptScore W119252893C2910542480 @default.
• W119252893 hasConceptScore W119252893C3018697912 @default.
• W119252893 hasConceptScore W119252893C55493867 @default.
• W119252893 hasConceptScore W119252893C62478195 @default.
• W119252893 hasConceptScore W119252893C86803240 @default.
• W119252893 hasConceptScore W119252893C87325107 @default.
• W119252893 hasConceptScore W119252893C89560881 @default.
• W119252893 hasConceptScore W119252893C95444343 @default.
• W119252893 hasConceptScore W119252893C97029542 @default.
• W119252893 hasIssue "12" @default.
• W119252893 hasLocation W1192528931 @default.
• W119252893 hasOpenAccess W119252893 @default.

• next