Matches in SemOpenAlex for { <https://semopenalex.org/work/W1192775462> ?p ?o ?g. }
Showing items 1 to 52 of
52
with 100 items per page.
- W1192775462 abstract "Vitamin D status during infancy is important for skeletal growth and development. Response to vitamin D3 supplementation is complicated by the presence of 3-epi-25-hydroxyvitamin D3 (3-epi-25-OH-D3). We undertook a small prospective study to simultaneously examine changes in 25-OH-D3, 3-epi-25-OH-D3 and 24,25-dihydroxyvitamin D3 (24,25-(OH)2D3) in preterm infants over the first five weeks after birth. Nineteen infants from Manitoba, born before 32 weeks of gestation and <1500 g, were included in the study. Plasma samples were obtained at the end of the first (wk1) and fifth (wk5) week after birth.Vitamin D metabolites were analyzed in triplicate using LC-MS/MS. Differences over time were tested using ANOVA and Bonferroni post hoc test, p<0.05. Mean gestational age at birth was 29.0 ± 1.5 weeks and birth weight 1144.5 ± 244.4 g. Total vitamin D intake increased over time (Table). Increases were observed in vitamin D status based on plasma 25-OH-D3 concentration over the first 5 weeks (wk1: 18.1 ± 7.1 vs wk5: 25.3 ± 10.6 ng/ml, p=0.02) as well as in 3-epi-25-OH-D3 (wk1: 5.1 ± 4.2 vs wk5: 20.0 ± 15.9 ng/ml, p<0.0001). Over the same time-period 24,25-(OH)2D3 (wk1: 0.9 ± 0.5 vs wk5: 0.7 ± 0.5 ng/ml, p=0.13) was not significantly changed.This work showed that 3-epi-25-OH-D3 increased over the first 5 weeks in parallel with increases of 25-OH-D3 while 24,25-(OH)2D3 was relatively stable suggesting the CYP24A1 activity does not readily mature during 5 weeks postnatally in prematurely born infants. Vitamin D intake from all sources (IU/day) Mean SD Min Max Week 1 202.8a 115.9 4.5 400.7 Week 2 189.3a 118.0 54.9 442.8 Week 3 250.8a 155.7 65.0 551.9 Week 4 366.2b 163.6 42.5 626.3 Week 5 489.3c 186.9 93.1 736.7 Week 6 515.9c 192.5 177.7 779.6 Means with different superscript letters are different, p<0.05" @default.
- W1192775462 created "2016-06-24" @default.
- W1192775462 creator A5013460050 @default.
- W1192775462 creator A5038634249 @default.
- W1192775462 creator A5039775439 @default.
- W1192775462 creator A5072357152 @default.
- W1192775462 date "2015-04-01" @default.
- W1192775462 modified "2023-09-27" @default.
- W1192775462 title "Plasma 3‐epi‐25‐hydroxyvitamin D3 in Very Low Birth Weight Preterm Infants in Canada During the First Five Weeks After Birth" @default.
- W1192775462 doi "https://doi.org/10.1096/fasebj.29.1_supplement.901.12" @default.
- W1192775462 hasPublicationYear "2015" @default.
- W1192775462 type Work @default.
- W1192775462 sameAs 1192775462 @default.
- W1192775462 citedByCount "0" @default.
- W1192775462 crossrefType "journal-article" @default.
- W1192775462 hasAuthorship W1192775462A5013460050 @default.
- W1192775462 hasAuthorship W1192775462A5038634249 @default.
- W1192775462 hasAuthorship W1192775462A5039775439 @default.
- W1192775462 hasAuthorship W1192775462A5072357152 @default.
- W1192775462 hasConcept C187212893 @default.
- W1192775462 hasConcept C2779083892 @default.
- W1192775462 hasConcept C2779234561 @default.
- W1192775462 hasConcept C54355233 @default.
- W1192775462 hasConcept C66322754 @default.
- W1192775462 hasConcept C71924100 @default.
- W1192775462 hasConcept C86803240 @default.
- W1192775462 hasConceptScore W1192775462C187212893 @default.
- W1192775462 hasConceptScore W1192775462C2779083892 @default.
- W1192775462 hasConceptScore W1192775462C2779234561 @default.
- W1192775462 hasConceptScore W1192775462C54355233 @default.
- W1192775462 hasConceptScore W1192775462C66322754 @default.
- W1192775462 hasConceptScore W1192775462C71924100 @default.
- W1192775462 hasConceptScore W1192775462C86803240 @default.
- W1192775462 hasIssue "S1" @default.
- W1192775462 hasLocation W11927754621 @default.
- W1192775462 hasOpenAccess W1192775462 @default.
- W1192775462 hasPrimaryLocation W11927754621 @default.
- W1192775462 hasRelatedWork W1999104473 @default.
- W1192775462 hasRelatedWork W2046482008 @default.
- W1192775462 hasRelatedWork W2082870743 @default.
- W1192775462 hasRelatedWork W2355894302 @default.
- W1192775462 hasRelatedWork W2365805804 @default.
- W1192775462 hasRelatedWork W2414995846 @default.
- W1192775462 hasRelatedWork W2469457165 @default.
- W1192775462 hasRelatedWork W2522982116 @default.
- W1192775462 hasRelatedWork W2624823026 @default.
- W1192775462 hasRelatedWork W2969584818 @default.
- W1192775462 hasVolume "29" @default.
- W1192775462 isParatext "false" @default.
- W1192775462 isRetracted "false" @default.
- W1192775462 magId "1192775462" @default.
- W1192775462 workType "article" @default.