Matches in SemOpenAlex for { <https://semopenalex.org/work/W119280068> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W119280068 endingPage "43" @default.
- W119280068 startingPage "139" @default.
- W119280068 abstract "The effects of propamidine and their dose dependency, on utilization of the third and fifth complement components in immune haemolysis have been compared. While C3 utilization is not disturbed that of C5 is markedly inhibited by propamidine in concentrations as low as 0.5 mM. Both, binding of C5 to surface-fixed C3b and cleavage of C5 by convertases C42 and C3bBb, are also inhibited in the presence of propamidine. Since neither C3 cleavage by these enzymes nor even C5 cleavage by the cobra venom factor-supported convertase CFVBb is significantly reduced a general convertase-inhibiting effect of propamidine is ruled out. Rather the effect on utilization of C5 is the result of interference with binding of C5 is the result of interference with binding of C5 to C3b and hence impairment of its accessibility to the convertases. These findings thus further support the role of surface fixed C3b in C5 activation proposed earlier." @default.
- W119280068 created "2016-06-24" @default.
- W119280068 creator A5043178272 @default.
- W119280068 creator A5078031658 @default.
- W119280068 creator A5089526969 @default.
- W119280068 date "1979-01-01" @default.
- W119280068 modified "2023-10-18" @default.
- W119280068 title "Interference of propamidine with binding of the fifth component of complement to surface-fixed C3b, and with C5 activation." @default.
- W119280068 cites W1493618746 @default.
- W119280068 cites W1648041042 @default.
- W119280068 cites W2027573846 @default.
- W119280068 cites W2409779712 @default.
- W119280068 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1457394" @default.
- W119280068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/422225" @default.
- W119280068 hasPublicationYear "1979" @default.
- W119280068 type Work @default.
- W119280068 sameAs 119280068 @default.
- W119280068 citedByCount "3" @default.
- W119280068 crossrefType "journal-article" @default.
- W119280068 hasAuthorship W119280068A5043178272 @default.
- W119280068 hasAuthorship W119280068A5078031658 @default.
- W119280068 hasAuthorship W119280068A5089526969 @default.
- W119280068 hasConcept C111684460 @default.
- W119280068 hasConcept C151730666 @default.
- W119280068 hasConcept C175156509 @default.
- W119280068 hasConcept C179369057 @default.
- W119280068 hasConcept C185592680 @default.
- W119280068 hasConcept C189446657 @default.
- W119280068 hasConcept C203014093 @default.
- W119280068 hasConcept C2910801743 @default.
- W119280068 hasConcept C43369102 @default.
- W119280068 hasConcept C86803240 @default.
- W119280068 hasConcept C8891405 @default.
- W119280068 hasConcept C9478725 @default.
- W119280068 hasConceptScore W119280068C111684460 @default.
- W119280068 hasConceptScore W119280068C151730666 @default.
- W119280068 hasConceptScore W119280068C175156509 @default.
- W119280068 hasConceptScore W119280068C179369057 @default.
- W119280068 hasConceptScore W119280068C185592680 @default.
- W119280068 hasConceptScore W119280068C189446657 @default.
- W119280068 hasConceptScore W119280068C203014093 @default.
- W119280068 hasConceptScore W119280068C2910801743 @default.
- W119280068 hasConceptScore W119280068C43369102 @default.
- W119280068 hasConceptScore W119280068C86803240 @default.
- W119280068 hasConceptScore W119280068C8891405 @default.
- W119280068 hasConceptScore W119280068C9478725 @default.
- W119280068 hasIssue "1" @default.
- W119280068 hasLocation W1192800681 @default.
- W119280068 hasOpenAccess W119280068 @default.
- W119280068 hasPrimaryLocation W1192800681 @default.
- W119280068 hasRelatedWork W119280068 @default.
- W119280068 hasRelatedWork W127121642 @default.
- W119280068 hasRelatedWork W13594097 @default.
- W119280068 hasRelatedWork W1973996890 @default.
- W119280068 hasRelatedWork W2030382685 @default.
- W119280068 hasRelatedWork W2399087400 @default.
- W119280068 hasRelatedWork W4228996633 @default.
- W119280068 hasRelatedWork W4281927551 @default.
- W119280068 hasRelatedWork W945493967 @default.
- W119280068 hasRelatedWork W2946078457 @default.
- W119280068 hasVolume "36" @default.
- W119280068 isParatext "false" @default.
- W119280068 isRetracted "false" @default.
- W119280068 magId "119280068" @default.
- W119280068 workType "article" @default.