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- W1193670502 abstract "Purpose To investigate the associations of measures of frailty to prevalent age-related maculopathy (ARM). Design Cross-sectional population-based study. Methods Time to walk a measured course (gait-time), handgrip strength, peak expiratory flow rate, ability to stand from a sitting position without using arms, self-reported co-morbidities, and ARM were assessed at the third examination of the Beaver Dam Eye Study (n = 2,962). ARM was determined by grading stereoscopic color fundus photographs. Results While controlling for age, smoking, and the number of co-morbid conditions, weaker handgrip strength was associated with early ARM (odds ratio [OR]/10 kg decrease 1.28, confidence interval [CI] 1.08, 1.52, P = .004) and late ARM (OR 1.55, 95% CI 1.02, 2.36) in men but not women. Other measures of frailty were not related to ARM. Conclusions A weak cross-sectional association of handgrip strength with ARM (in men) was found after controlling for co-morbid conditions. These data suggest that ARM is due to a specific disease process, albeit age-related, rather than to biologic aging, as reflected by measures of frailty." @default.
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- W1193670502 date "2004-05-01" @default.
- W1193670502 modified "2023-09-27" @default.
- W1193670502 title "Frailty and Age–related Macular Degeneration. The Beaver Dam Eye Study." @default.
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