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- W119377568 abstract "In human platelets, intracellular Ca/sup 2 +/ is a second messenger for platelet agonists. Two targets for the Ca/sup 2 +/ signal are calmodulin and the C-,inase; however, other Ca/sup 2 +/-binding proteins may also play a role in platelet function. The Western blotting technique of Maruyama et al., which utilizes /sup 45/Ca/sup 2 +/ to detect Ca/sup 2 +/-binding proteins, has been used to identify numerous platelet Ca/sup 2 +/-binding proteins ranging in molecular weight from 165K to 15K. The greatest quantity of /sup 45/Ca/sup 2 +/ was bound to a 165 kilodalton protein which has been identified as thrombospondin based upon its release from thrombin-stimulated platelets and its comigration on SDS gels with purified thrombospondin. Two other major sites for /sup 45/Ca/sup 2 +/-binding correspond to proteins of 120K and 108K which are present only in the platelet particulate fraction; they have been identified as glycoproteins IIb and IIIa based upon their labeling by /sup 125/I-concanavalin A. Two proteins with molecular weights of 20K and 15K bound much less /sup 45/Ca/sup 2 +/ and correspond on SDS gels to calmodulin and subunit B of the calmodulin-dependent phosphatase. A number of other, yet to be identified, Ca/sup 2 +/-bindingmore » proteins were also detected. These data indicate that human platelets contain numerous Ca/sup 2 +/-binding proteins and that Western blotting techniques utilizing /sup 45/Ca/sup 2 +/ may be useful as an assay system in future attempts to purify platelet Ca/sup 2 +/-binding proteins.« less" @default.
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- W119377568 date "1986-05-01" @default.
- W119377568 modified "2023-09-24" @default.
- W119377568 title "Identification of calcium-binding proteins in human platelets" @default.
- W119377568 hasPublicationYear "1986" @default.
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