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- W1194841186 abstract "This chapter discusses the assay of coumarin antagonists of vitamin K in blood by high-performance liquid chromatography (HPLC), and describes the procedures which is given for the assay in plasma of a typical and widely used clinical anticoagulant, warfarin, by both reverse-phase and normal-phase methods. Both reverse-phase and normal-phase methods may be carried out with a standard HPLC pump and a ultraviolet (UV) photometer, preferably a variable wavelength instrument able to operate at the optimal wavelength of 305 nm. Sample extracts are injected via a syringe-loading injection valve fitted with a 100 μ l loop. In the reverse-phase method, warfarin metabolites, being more polar than warfarin, elute before the parent drug. The normal-phase method, however, conveniently resolves warfarin from its major metabolites—namely, warfarin alcohols (both pairs of diastereoisomers eluting as a single peak), 6-, 7-, 8-, and 4 ' -hydroxywarfarin—and allows these to be measured concurrently if present in sufficient concentrations. Even when as little as 100 μ l of plasma is extracted, peaks corresponding to warfarin alcohols and 7-hydroxywarfarin are regularly detected in plasma from patients on warfarin therapy and occasionally a small peak is seen which corresponds to 6-hydroxywarfarin. The design of the normal-phase method is preferred because of the facility in being able to make direct injections of the extracting solvent onto the HPLC column." @default.
- W1194841186 created "2016-06-24" @default.
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- W1194841186 date "1986-01-01" @default.
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- W1194841186 title "[24] Assay of coumarin antagonists of vitamin K in blood by high-performance liquid chromatography" @default.
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- W1194841186 doi "https://doi.org/10.1016/s0076-6879(86)23026-8" @default.
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