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- W119546816 abstract "Objectives: Gastroprotective therapy is recommended for cardiovascular (CV) patients (pts) taking low-dose aspirin (LDA) and at increased gastrointestinal risk, eg history of peptic ulcer. This study assessed the potential effects of esomeprazole (ESO) in prevention of recurrent peptic (gastric and/or duodenal) ulcer in East Asian pts taking LDA for CV protection. Methods: Pts aged >=20y with history of endoscopically confirmed peptic ulcer and taking LDA (81-324mg/d) for CV protection were enrolled (NCT01069939). Pts with serious heart failure/unstable hypertension/history of acute coronary syndromes were excluded. Eligible pts were randomized to ESO 20mg/d or placebo (PBO) for a maximum of 72 wks. All pts received concomitant mucosal protection (gefarnate 100mg/d). Primary end point was time to ulcer recurrence, analyzed by the Kaplan-Meier method. Findings are presented up to wk 60, as per a planned event-driven analysis. Results: A total of 427 pts (mean age 67y; 79% men) comprised the full analysis s..." @default.
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- W119546816 date "2012-11-20" @default.
- W119546816 modified "2023-09-22" @default.
- W119546816 title "Abstract 9048: Once-Daily Esomeprazole 20mg Prevents Recurrence of Peptic Ulcer in East Asian Low-Dose Aspirin Users at Gastrointestinal Risk: the LAVENDER Study" @default.
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