Matches in SemOpenAlex for { <https://semopenalex.org/work/W119577919> ?p ?o ?g. }
- W119577919 abstract "Abstract : To develop and evaluate novel compounds which inhibit the C-terminal portion of Hsp90 in prostate cancer models. To develop a library of novobiocin analogues to be tested in vitro initially and then in a mouse model. Major findings: we have tested over 220 analogues of the original parent compound (A-1) all of which have been tested in at least two commonly used prostate cancer cell lines LNCaP and PC3. Screening has been evaluated by both Western Blot of client proteins which include the androgen receptor, Akt, Hsp90, and HER2, and MTT assay. Furthermore, with our most effective compounds we have examined the mechanism of action and have examined cell cycle data. We have evaluated one compound in vivo and are currently evaluating our newest most promising compound in vivo in an orthotopic mouse model." @default.
- W119577919 created "2016-06-24" @default.
- W119577919 creator A5077312194 @default.
- W119577919 date "2008-10-01" @default.
- W119577919 modified "2023-09-24" @default.
- W119577919 title "Development of the C-Terminal Inhibitors of Heat Shock Protein 90 in the Treatment of Prostate Cancer" @default.
- W119577919 cites W1971190195 @default.
- W119577919 cites W1972370905 @default.
- W119577919 cites W1976491209 @default.
- W119577919 cites W1988451921 @default.
- W119577919 cites W1999763581 @default.
- W119577919 cites W2000929246 @default.
- W119577919 cites W2007106751 @default.
- W119577919 cites W2020742237 @default.
- W119577919 cites W2034930480 @default.
- W119577919 cites W2051275249 @default.
- W119577919 cites W2054290614 @default.
- W119577919 cites W2080439368 @default.
- W119577919 cites W2120292596 @default.
- W119577919 cites W2134919261 @default.
- W119577919 cites W2170427853 @default.
- W119577919 cites W2186655833 @default.
- W119577919 doi "https://doi.org/10.21236/ada496320" @default.
- W119577919 hasPublicationYear "2008" @default.
- W119577919 type Work @default.
- W119577919 sameAs 119577919 @default.
- W119577919 citedByCount "0" @default.
- W119577919 crossrefType "report" @default.
- W119577919 hasAuthorship W119577919A5077312194 @default.
- W119577919 hasConcept C104317684 @default.
- W119577919 hasConcept C121608353 @default.
- W119577919 hasConcept C126322002 @default.
- W119577919 hasConcept C185592680 @default.
- W119577919 hasConcept C202751555 @default.
- W119577919 hasConcept C205260736 @default.
- W119577919 hasConcept C207001950 @default.
- W119577919 hasConcept C2775932338 @default.
- W119577919 hasConcept C2776120743 @default.
- W119577919 hasConcept C2776235491 @default.
- W119577919 hasConcept C2776415932 @default.
- W119577919 hasConcept C2779723316 @default.
- W119577919 hasConcept C2780192828 @default.
- W119577919 hasConcept C2780783641 @default.
- W119577919 hasConcept C502942594 @default.
- W119577919 hasConcept C54355233 @default.
- W119577919 hasConcept C55493867 @default.
- W119577919 hasConcept C61367390 @default.
- W119577919 hasConcept C62478195 @default.
- W119577919 hasConcept C71924100 @default.
- W119577919 hasConcept C75217442 @default.
- W119577919 hasConcept C86803240 @default.
- W119577919 hasConcept C98274493 @default.
- W119577919 hasConceptScore W119577919C104317684 @default.
- W119577919 hasConceptScore W119577919C121608353 @default.
- W119577919 hasConceptScore W119577919C126322002 @default.
- W119577919 hasConceptScore W119577919C185592680 @default.
- W119577919 hasConceptScore W119577919C202751555 @default.
- W119577919 hasConceptScore W119577919C205260736 @default.
- W119577919 hasConceptScore W119577919C207001950 @default.
- W119577919 hasConceptScore W119577919C2775932338 @default.
- W119577919 hasConceptScore W119577919C2776120743 @default.
- W119577919 hasConceptScore W119577919C2776235491 @default.
- W119577919 hasConceptScore W119577919C2776415932 @default.
- W119577919 hasConceptScore W119577919C2779723316 @default.
- W119577919 hasConceptScore W119577919C2780192828 @default.
- W119577919 hasConceptScore W119577919C2780783641 @default.
- W119577919 hasConceptScore W119577919C502942594 @default.
- W119577919 hasConceptScore W119577919C54355233 @default.
- W119577919 hasConceptScore W119577919C55493867 @default.
- W119577919 hasConceptScore W119577919C61367390 @default.
- W119577919 hasConceptScore W119577919C62478195 @default.
- W119577919 hasConceptScore W119577919C71924100 @default.
- W119577919 hasConceptScore W119577919C75217442 @default.
- W119577919 hasConceptScore W119577919C86803240 @default.
- W119577919 hasConceptScore W119577919C98274493 @default.
- W119577919 hasLocation W1195779191 @default.
- W119577919 hasOpenAccess W119577919 @default.
- W119577919 hasPrimaryLocation W1195779191 @default.
- W119577919 hasRelatedWork W1534604861 @default.
- W119577919 hasRelatedWork W1872224956 @default.
- W119577919 hasRelatedWork W2000950187 @default.
- W119577919 hasRelatedWork W2013431834 @default.
- W119577919 hasRelatedWork W2083030025 @default.
- W119577919 hasRelatedWork W2131717345 @default.
- W119577919 hasRelatedWork W2328051402 @default.
- W119577919 hasRelatedWork W2464052734 @default.
- W119577919 hasRelatedWork W2546920149 @default.
- W119577919 hasRelatedWork W2550764931 @default.
- W119577919 hasRelatedWork W2568024305 @default.
- W119577919 hasRelatedWork W2734609837 @default.
- W119577919 hasRelatedWork W2742000871 @default.
- W119577919 hasRelatedWork W276251265 @default.
- W119577919 hasRelatedWork W3024831283 @default.
- W119577919 hasRelatedWork W3038534374 @default.
- W119577919 hasRelatedWork W3041974149 @default.
- W119577919 hasRelatedWork W3137621245 @default.
- W119577919 hasRelatedWork W3164167956 @default.
- W119577919 hasRelatedWork W986448973 @default.
- W119577919 isParatext "false" @default.
- W119577919 isRetracted "false" @default.