Matches in SemOpenAlex for { <https://semopenalex.org/work/W119701119> ?p ?o ?g. }
- W119701119 endingPage "2593" @default.
- W119701119 startingPage "2583" @default.
- W119701119 abstract "Abstract Interferon (IFN)-alpha inhibits DNA synthesis stimulated by low molecular weight B-cell growth factor (BCGF) in hairy cells in vitro, suggesting that the therapeutic efficacy of IFN-alpha in hairy cell leukemia (HCL) involves growth inhibition of malignant B cells. Evidence that the 16-Kd cell surface protein Leu-13 mediates an antiproliferative signal in T lymphocytes and is IFN-inducible in endothelial cells prompted us to examine the expression and functional role of this molecule in leukemic B cells. Leu-13 density, determined by flow cytometry, was upregulated in vitro and in vivo by IFN-alpha on malignant B cells from patients with HCL, chronic lymphocytic leukemia, and prolymphocytic leukemia. Monoclonal anti-Leu-13 triggered homotypic aggregation of leukemic B cells via an adhesion pathway that was not inhibited by antibodies to leukocyte function associated antigen-1 (LFA- 1) or intercellular adhesion molecule-1 (ICAM-1). Moreover, anti-Leu-13 potentiated the inhibitory effects of IFN-alpha on BCGF-stimulated DNA synthesis, assessed by [3H]-thymidine and [3H]-deoxyadenosine incorporation into DNA. These results indicate that Leu-13 is part of a novel IFN-inducible signaling pathway which may modify the growth and adhesive properties of leukemic B cells under physiologic or therapeutic conditions." @default.
- W119701119 created "2016-06-24" @default.
- W119701119 creator A5001024551 @default.
- W119701119 creator A5005248918 @default.
- W119701119 creator A5012145337 @default.
- W119701119 creator A5031896792 @default.
- W119701119 creator A5043544229 @default.
- W119701119 date "1990-12-15" @default.
- W119701119 modified "2023-10-06" @default.
- W119701119 title "Monoclonal antibody to the interferon-inducible protein Leu-13 triggers aggregation and inhibits proliferation of leukemic B cells" @default.
- W119701119 cites W100209535 @default.
- W119701119 cites W1483035379 @default.
- W119701119 cites W1489856963 @default.
- W119701119 cites W1502100878 @default.
- W119701119 cites W1504058752 @default.
- W119701119 cites W1506861226 @default.
- W119701119 cites W1520971963 @default.
- W119701119 cites W1545686401 @default.
- W119701119 cites W1548735291 @default.
- W119701119 cites W1560772756 @default.
- W119701119 cites W156282808 @default.
- W119701119 cites W15675347 @default.
- W119701119 cites W159437619 @default.
- W119701119 cites W1660326925 @default.
- W119701119 cites W1812173233 @default.
- W119701119 cites W1966738174 @default.
- W119701119 cites W1978242550 @default.
- W119701119 cites W1981764405 @default.
- W119701119 cites W1995680590 @default.
- W119701119 cites W2012316443 @default.
- W119701119 cites W2020971843 @default.
- W119701119 cites W2030124997 @default.
- W119701119 cites W2065064062 @default.
- W119701119 cites W2065308713 @default.
- W119701119 cites W207455869 @default.
- W119701119 cites W2077702220 @default.
- W119701119 cites W2081563161 @default.
- W119701119 cites W2083660426 @default.
- W119701119 cites W2090169073 @default.
- W119701119 cites W2108067576 @default.
- W119701119 cites W2115536654 @default.
- W119701119 cites W2122216009 @default.
- W119701119 cites W2134003607 @default.
- W119701119 cites W2157279574 @default.
- W119701119 cites W2161239928 @default.
- W119701119 cites W2177943720 @default.
- W119701119 cites W2245073157 @default.
- W119701119 cites W226094559 @default.
- W119701119 cites W2339387502 @default.
- W119701119 cites W2343089983 @default.
- W119701119 cites W2359571009 @default.
- W119701119 cites W2406821753 @default.
- W119701119 cites W2409309219 @default.
- W119701119 cites W2413949949 @default.
- W119701119 cites W2419236645 @default.
- W119701119 cites W2419284364 @default.
- W119701119 cites W2430158471 @default.
- W119701119 cites W2439205875 @default.
- W119701119 cites W2462775530 @default.
- W119701119 cites W2472792927 @default.
- W119701119 cites W3113367021 @default.
- W119701119 cites W344318876 @default.
- W119701119 cites W53642436 @default.
- W119701119 cites W8015635 @default.
- W119701119 doi "https://doi.org/10.1182/blood.v76.12.2583.2583" @default.
- W119701119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2265250" @default.
- W119701119 hasPublicationYear "1990" @default.
- W119701119 type Work @default.
- W119701119 sameAs 119701119 @default.
- W119701119 citedByCount "78" @default.
- W119701119 countsByYear W1197011192012 @default.
- W119701119 countsByYear W1197011192013 @default.
- W119701119 countsByYear W1197011192014 @default.
- W119701119 countsByYear W1197011192015 @default.
- W119701119 countsByYear W1197011192016 @default.
- W119701119 countsByYear W1197011192017 @default.
- W119701119 countsByYear W1197011192018 @default.
- W119701119 countsByYear W1197011192019 @default.
- W119701119 countsByYear W1197011192020 @default.
- W119701119 countsByYear W1197011192021 @default.
- W119701119 countsByYear W1197011192022 @default.
- W119701119 countsByYear W1197011192023 @default.
- W119701119 crossrefType "journal-article" @default.
- W119701119 hasAuthorship W119701119A5001024551 @default.
- W119701119 hasAuthorship W119701119A5005248918 @default.
- W119701119 hasAuthorship W119701119A5012145337 @default.
- W119701119 hasAuthorship W119701119A5031896792 @default.
- W119701119 hasAuthorship W119701119A5043544229 @default.
- W119701119 hasBestOaLocation W1197011191 @default.
- W119701119 hasConcept C1491633281 @default.
- W119701119 hasConcept C153911025 @default.
- W119701119 hasConcept C159654299 @default.
- W119701119 hasConcept C202751555 @default.
- W119701119 hasConcept C203014093 @default.
- W119701119 hasConcept C2778461978 @default.
- W119701119 hasConcept C2780483514 @default.
- W119701119 hasConcept C2910537785 @default.
- W119701119 hasConcept C502942594 @default.