Matches in SemOpenAlex for { <https://semopenalex.org/work/W1197558456> ?p ?o ?g. }
- W1197558456 endingPage "355" @default.
- W1197558456 startingPage "337" @default.
- W1197558456 abstract "To better estimate the potential therapeutic value of gangliosides or neurotrophins in central nervous system (CNS) trauma or degenerative processes, this chapter presents the rodent experimental model, involving loss of a portion of the cortical cholinergic network of nucleus basalis magnocellularis (nbm) projections in subhuman primates. A similar cholinergic atrophic reaction was elicited in primates (Cercopithecus aethiops) and the neurotrophic therapy was equally effective in such animals. The details of these investigations are also discussed in this chapter. The studies applying putative neurotrophic agents (NGF) in the cholinergic basolo-cortical lesion model suggested that these substances might induce an important re-arrangement of the cholinergic innervations. The chapter also investigates the incidence of CUT-IR varicosities in animals as these are sites for storage of acetylcholine as well as the enzyme involved in its synthesis, and are where physiological release of the neurotransmitter occurs. This study was accomplished by using a image analysis system combined with immunohistochemistry, except that 24 fields per animal were scanned at higher magnification. The program employed was designed to recognize immunoreactive elements, falling within the size range of nerve varicosities, along fibers." @default.
- W1197558456 created "2016-06-24" @default.
- W1197558456 creator A5013749591 @default.
- W1197558456 creator A5017648912 @default.
- W1197558456 creator A5033125462 @default.
- W1197558456 creator A5045753706 @default.
- W1197558456 date "1994-01-01" @default.
- W1197558456 modified "2023-09-25" @default.
- W1197558456 title "Chapter 26 Cooperative effects of gangliosides on trophic factor-induced neuronal cell recovery and synaptogenesis: studies in rodents and subhuman primates" @default.
- W1197558456 cites W127964384 @default.
- W1197558456 cites W1505755593 @default.
- W1197558456 cites W1508039723 @default.
- W1197558456 cites W1517117095 @default.
- W1197558456 cites W1582530932 @default.
- W1197558456 cites W1609471181 @default.
- W1197558456 cites W1639832183 @default.
- W1197558456 cites W1820424262 @default.
- W1197558456 cites W1824128596 @default.
- W1197558456 cites W1842398497 @default.
- W1197558456 cites W1968025922 @default.
- W1197558456 cites W1972731436 @default.
- W1197558456 cites W1979406476 @default.
- W1197558456 cites W1984491883 @default.
- W1197558456 cites W1985036040 @default.
- W1197558456 cites W1985822867 @default.
- W1197558456 cites W1991004967 @default.
- W1197558456 cites W1993912261 @default.
- W1197558456 cites W1997325586 @default.
- W1197558456 cites W1998397185 @default.
- W1197558456 cites W1998606454 @default.
- W1197558456 cites W1998939554 @default.
- W1197558456 cites W1999487668 @default.
- W1197558456 cites W1999984945 @default.
- W1197558456 cites W2000277057 @default.
- W1197558456 cites W2005780620 @default.
- W1197558456 cites W2011821188 @default.
- W1197558456 cites W2012713559 @default.
- W1197558456 cites W2013854477 @default.
- W1197558456 cites W2014648886 @default.
- W1197558456 cites W2015379420 @default.
- W1197558456 cites W2019997262 @default.
- W1197558456 cites W2021860872 @default.
- W1197558456 cites W2022599922 @default.
- W1197558456 cites W2022908085 @default.
- W1197558456 cites W2023248571 @default.
- W1197558456 cites W2023743366 @default.
- W1197558456 cites W2028277234 @default.
- W1197558456 cites W2028641623 @default.
- W1197558456 cites W2030176564 @default.
- W1197558456 cites W2032325605 @default.
- W1197558456 cites W2033367566 @default.
- W1197558456 cites W2035471834 @default.
- W1197558456 cites W2037338304 @default.
- W1197558456 cites W2038216975 @default.
- W1197558456 cites W2040700904 @default.
- W1197558456 cites W2043421056 @default.
- W1197558456 cites W2044521513 @default.
- W1197558456 cites W2044758689 @default.
- W1197558456 cites W2045414227 @default.
- W1197558456 cites W2045776001 @default.
- W1197558456 cites W2046096408 @default.
- W1197558456 cites W2046656280 @default.
- W1197558456 cites W2047945439 @default.
- W1197558456 cites W2050030644 @default.
- W1197558456 cites W2051485994 @default.
- W1197558456 cites W2053341391 @default.
- W1197558456 cites W2053684741 @default.
- W1197558456 cites W2056072653 @default.
- W1197558456 cites W2056941695 @default.
- W1197558456 cites W2058650902 @default.
- W1197558456 cites W2059667376 @default.
- W1197558456 cites W2065171993 @default.
- W1197558456 cites W2065538605 @default.
- W1197558456 cites W2069095254 @default.
- W1197558456 cites W2071857166 @default.
- W1197558456 cites W2073383817 @default.
- W1197558456 cites W2073611916 @default.
- W1197558456 cites W2075690578 @default.
- W1197558456 cites W2078626049 @default.
- W1197558456 cites W2079742986 @default.
- W1197558456 cites W2080880626 @default.
- W1197558456 cites W2084351892 @default.
- W1197558456 cites W2085230456 @default.
- W1197558456 cites W2085533627 @default.
- W1197558456 cites W2088479689 @default.
- W1197558456 cites W2088889614 @default.
- W1197558456 cites W2089454493 @default.
- W1197558456 cites W2091011317 @default.
- W1197558456 cites W2091309613 @default.
- W1197558456 cites W2092031334 @default.
- W1197558456 cites W2093374391 @default.
- W1197558456 cites W2093613378 @default.
- W1197558456 cites W2094335493 @default.
- W1197558456 cites W2095873344 @default.
- W1197558456 cites W2096812703 @default.
- W1197558456 cites W2098862614 @default.
- W1197558456 cites W2100006227 @default.
- W1197558456 cites W2118626586 @default.