Matches in SemOpenAlex for { <https://semopenalex.org/work/W119759939> ?p ?o ?g. }
Showing items 1 to 53 of
53
with 100 items per page.
- W119759939 endingPage "9" @default.
- W119759939 startingPage "175" @default.
- W119759939 abstract "To test the hypothesis that the dose requirement for local anesthetics is changed in aged animals, the effects of two different local anesthetics on nerve conduction block were tested in young and old rats. Young (6 months) and old (27 months) male Fisher-344 rats were anesthetized with intraperitoneal pentobarbital and diazepam. Stimulating electrodes were placed in the sciatic notch and in the ankle and recording electrodes were placed distally in the ipsilateral foot to record evoked electrical activity of the interosseous muscles. Motor nerve conduction velocity was significantly less in old (48.8 +/- 3.9, mean +/- SD m.sec-1) than in young rats (56.4 +/- 10.3 m.sec-1) (P < 0.05). To test the effects of aging on conduction block, equipotent doses of bupivacaine (0.2%), an amide-linked local anesthetic, or procaine (0.6%), an ester-linked local anesthetic, were injected next to exposed sciatic nerves and evoked electrical activity was monitored following repeated stimulation at the sciatic notch. At 10 minutes after injection, bupivacaine produced significantly greater nerve block in old rats (100 +/- 0.0%) than young rats (29.8 +/- 41.6%) (P < 0.01); the difference for procaine (old 67.5 +/- 40.4% vs. young 30.4 +/- 35.3%) was not statistically significant. The lower dose requirement for bupivacaine, and the apparent differences compared to procaine, may have implications for the use of local anesthetics in an aging patient population." @default.
- W119759939 created "2016-06-24" @default.
- W119759939 creator A5041131519 @default.
- W119759939 creator A5074904679 @default.
- W119759939 date "1997-01-01" @default.
- W119759939 modified "2023-09-23" @default.
- W119759939 title "Effects of aging on nerve conduction block induced by bupivacaine and procaine in rats." @default.
- W119759939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10959231" @default.
- W119759939 hasPublicationYear "1997" @default.
- W119759939 type Work @default.
- W119759939 sameAs 119759939 @default.
- W119759939 citedByCount "2" @default.
- W119759939 countsByYear W1197599392015 @default.
- W119759939 crossrefType "journal-article" @default.
- W119759939 hasAuthorship W119759939A5041131519 @default.
- W119759939 hasAuthorship W119759939A5074904679 @default.
- W119759939 hasConcept C2777197265 @default.
- W119759939 hasConcept C2778994108 @default.
- W119759939 hasConcept C2779828710 @default.
- W119759939 hasConcept C2780149897 @default.
- W119759939 hasConcept C2781149210 @default.
- W119759939 hasConcept C2781328992 @default.
- W119759939 hasConcept C42219234 @default.
- W119759939 hasConcept C71924100 @default.
- W119759939 hasConceptScore W119759939C2777197265 @default.
- W119759939 hasConceptScore W119759939C2778994108 @default.
- W119759939 hasConceptScore W119759939C2779828710 @default.
- W119759939 hasConceptScore W119759939C2780149897 @default.
- W119759939 hasConceptScore W119759939C2781149210 @default.
- W119759939 hasConceptScore W119759939C2781328992 @default.
- W119759939 hasConceptScore W119759939C42219234 @default.
- W119759939 hasConceptScore W119759939C71924100 @default.
- W119759939 hasIssue "2" @default.
- W119759939 hasLocation W1197599391 @default.
- W119759939 hasOpenAccess W119759939 @default.
- W119759939 hasPrimaryLocation W1197599391 @default.
- W119759939 hasRelatedWork W119759939 @default.
- W119759939 hasRelatedWork W1988510620 @default.
- W119759939 hasRelatedWork W2006110910 @default.
- W119759939 hasRelatedWork W2037617419 @default.
- W119759939 hasRelatedWork W2055511613 @default.
- W119759939 hasRelatedWork W2075472072 @default.
- W119759939 hasRelatedWork W2081210235 @default.
- W119759939 hasRelatedWork W2388150591 @default.
- W119759939 hasRelatedWork W2883387211 @default.
- W119759939 hasRelatedWork W3088560420 @default.
- W119759939 hasVolume "2" @default.
- W119759939 isParatext "false" @default.
- W119759939 isRetracted "false" @default.
- W119759939 magId "119759939" @default.
- W119759939 workType "article" @default.