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- W119891185 abstract "Functionally active dense bodies (5-HT storage organelles) have been isolated from human platelets following centrifugation of platelet lysates on a two step discontinuous metrizamide gradient. Their purification was followed using platelets loaded with either (i) [14C]-5HT or (ii) mepacrine, a fluorescent dye selectively accumulated by the dense bodies. The isolated granules gave the typical appearance of dense bodies when examined by electron microscopy and were able to rapidly incorporate 5-HT; this incorporation was unaffected by imipramine but was strongly inhibited by reserpine." @default.
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- W119891185 date "1979-01-01" @default.
- W119891185 modified "2023-09-27" @default.
- W119891185 title "Isolation of Dense Bodies from Human Blood Platelets Using Discontinuous Metrizamide Gradients" @default.
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- W119891185 doi "https://doi.org/10.1016/b978-0-08-024957-5.50019-7" @default.
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