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- W119893552 endingPage "175" @default.
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- W119893552 abstract "Publisher Summary Systemic lupus erythematosus (SLE) is a disease state posing several challenges to the clinician, including heterogeneity of presentation, undulating course, and an extraordinary risk for vascular injury including premature atherosclerosis as well as endothelial injury related to renal disease. Central to this concept is a focus largely on the endothelium, since it provides the physiologic boundary that limits extravasation and diapedesis of inflammatory cells. This chapter provides a clinical overview and outlines the putative pathogenic events that occur in SLE autoimmune-associated vasculopathy for atherosclerosis and renal disease. Vascular manifestations associated with systemic lupus erythematosus (SLE) span a broad range including vasculopathy. Adipocyte-derived protein, adiponectin, and membrane endothelial protein C receptor (mEPCR) may serve as biomarkers of morbidities involving premature atherosclerosis and vascular injury in nephritis, respectively. This chapter focuses on the structures of adiponectin and membrane EPCR and their expression in the context of the proinflammatory CR3-dependent signaling pathways. Finally, it reviews pathogenesis in the context of the “inflammation” hypothesis and Schwartzman phenomenon and discusses the implications of a putative risk profile of vascular injury that includes a genetic factor (SNP within an exon of the extracellular domain of the alpha chain of CR3) and environmental factors that are related to pathogenic consequences of Th1 cells and cytokines." @default.
- W119893552 created "2016-06-24" @default.
- W119893552 creator A5018452221 @default.
- W119893552 date "2011-01-01" @default.
- W119893552 modified "2023-09-27" @default.
- W119893552 title "Polymorphonuclear and Endothelial Cells" @default.
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