Matches in SemOpenAlex for { <https://semopenalex.org/work/W119941668> ?p ?o ?g. }
- W119941668 endingPage "786" @default.
- W119941668 startingPage "777" @default.
- W119941668 abstract "Whooping cough is a highly contagious respiratory disease caused by Bordetella pertussis (B. pertussis). T helper 17 (Th17) cells have a central role in the resolution of the infection. Emerging studies document that type I interferons (IFNs) suppress Th17 differentiation and interleukin (IL)-17 responses in models of infection and chronic inflammation. As plasmacytoid dendritic cells (pDCs) are a major source of type I IFNs, we hypothesize that during B. pertussis infection in mice, pDC-derived IFNα inhibits a rapid increase in Th17 cells. We found that IFNα-secreting pDCs appear in the lungs during the early stages of infection, while a robust rise of Th17 cells in the lungs is detected at 15 days post-infection or later. The presence of IFNα led to reduced Th17 differentiation and proliferation in vitro. Furthermore, in vivo blocking of IFNα produced by pDCs during infection with B. pertussis infection resulted in early increase of Th17 frequency, inflammation, and reduced bacterial loads in the airways of infected mice. Taken together, the experiments reported here describe an inhibitory role for pDCs and pDC-derived IFNα in modulating Th17 responses during the early stages of B. pertussis infection, which may explain the prolonged nature of whooping cough." @default.
- W119941668 created "2016-06-24" @default.
- W119941668 creator A5014137651 @default.
- W119941668 creator A5025586566 @default.
- W119941668 creator A5037997217 @default.
- W119941668 creator A5042159744 @default.
- W119941668 creator A5051791060 @default.
- W119941668 creator A5053817588 @default.
- W119941668 creator A5054052298 @default.
- W119941668 creator A5056925040 @default.
- W119941668 creator A5089358310 @default.
- W119941668 creator A5089731628 @default.
- W119941668 date "2016-05-01" @default.
- W119941668 modified "2023-10-14" @default.
- W119941668 title "Plasmacytoid dendritic cell-derived IFNα modulates Th17 differentiation during early Bordetella pertussis infection in mice" @default.
- W119941668 cites W1808881512 @default.
- W119941668 cites W1854638296 @default.
- W119941668 cites W1884169158 @default.
- W119941668 cites W1925863651 @default.
- W119941668 cites W1927634469 @default.
- W119941668 cites W1964057155 @default.
- W119941668 cites W1976261698 @default.
- W119941668 cites W1978741561 @default.
- W119941668 cites W1981032637 @default.
- W119941668 cites W1992838083 @default.
- W119941668 cites W1998835047 @default.
- W119941668 cites W1999561404 @default.
- W119941668 cites W2001249476 @default.
- W119941668 cites W2001888818 @default.
- W119941668 cites W2016297238 @default.
- W119941668 cites W2019718742 @default.
- W119941668 cites W2032894542 @default.
- W119941668 cites W2034389602 @default.
- W119941668 cites W2036463856 @default.
- W119941668 cites W2041693925 @default.
- W119941668 cites W2054521437 @default.
- W119941668 cites W2055254020 @default.
- W119941668 cites W2061217789 @default.
- W119941668 cites W2065620817 @default.
- W119941668 cites W2071355807 @default.
- W119941668 cites W2082602434 @default.
- W119941668 cites W2088199958 @default.
- W119941668 cites W2094488151 @default.
- W119941668 cites W2102195613 @default.
- W119941668 cites W2102726155 @default.
- W119941668 cites W2102784438 @default.
- W119941668 cites W2112133235 @default.
- W119941668 cites W2118647619 @default.
- W119941668 cites W2119383231 @default.
- W119941668 cites W2123440892 @default.
- W119941668 cites W2123805324 @default.
- W119941668 cites W2126397566 @default.
- W119941668 cites W2127369880 @default.
- W119941668 cites W2129868260 @default.
- W119941668 cites W2130419890 @default.
- W119941668 cites W2131297439 @default.
- W119941668 cites W2135165124 @default.
- W119941668 cites W2138591665 @default.
- W119941668 cites W2139977061 @default.
- W119941668 cites W2142582441 @default.
- W119941668 cites W2147111692 @default.
- W119941668 cites W2149926345 @default.
- W119941668 cites W2151109138 @default.
- W119941668 cites W2153520219 @default.
- W119941668 cites W2157758507 @default.
- W119941668 cites W4230268840 @default.
- W119941668 doi "https://doi.org/10.1038/mi.2015.101" @default.
- W119941668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26462419" @default.
- W119941668 hasPublicationYear "2016" @default.
- W119941668 type Work @default.
- W119941668 sameAs 119941668 @default.
- W119941668 citedByCount "16" @default.
- W119941668 countsByYear W1199416682016 @default.
- W119941668 countsByYear W1199416682017 @default.
- W119941668 countsByYear W1199416682018 @default.
- W119941668 countsByYear W1199416682019 @default.
- W119941668 countsByYear W1199416682020 @default.
- W119941668 countsByYear W1199416682021 @default.
- W119941668 countsByYear W1199416682022 @default.
- W119941668 countsByYear W1199416682023 @default.
- W119941668 crossrefType "journal-article" @default.
- W119941668 hasAuthorship W119941668A5014137651 @default.
- W119941668 hasAuthorship W119941668A5025586566 @default.
- W119941668 hasAuthorship W119941668A5037997217 @default.
- W119941668 hasAuthorship W119941668A5042159744 @default.
- W119941668 hasAuthorship W119941668A5051791060 @default.
- W119941668 hasAuthorship W119941668A5053817588 @default.
- W119941668 hasAuthorship W119941668A5054052298 @default.
- W119941668 hasAuthorship W119941668A5056925040 @default.
- W119941668 hasAuthorship W119941668A5089358310 @default.
- W119941668 hasAuthorship W119941668A5089731628 @default.
- W119941668 hasBestOaLocation W1199416681 @default.
- W119941668 hasConcept C203014093 @default.
- W119941668 hasConcept C22070199 @default.
- W119941668 hasConcept C2776178377 @default.
- W119941668 hasConcept C2776914184 @default.
- W119941668 hasConcept C2777582894 @default.
- W119941668 hasConcept C2779214499 @default.