Matches in SemOpenAlex for { <https://semopenalex.org/work/W119953189> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W119953189 endingPage "20" @default.
- W119953189 startingPage "115" @default.
- W119953189 abstract "Crohn's disease and ulcerative colitis are chronic inflammatory diseases of the bowel with unknown etiology. Alterations of intestinal and systemic immuno-regulation are probably of importance in the pathophysiology of both diseases. Moreover, recent studies suggest that polymorphonuclear granulocytes and probably macrophages are of particular importance in the initiation of an acute flare of the disease. Interest has therefore focused on arachidonic acid metabolites, in particular leukotrienes and prostaglandins, which are important mediators in granulocyte and macrophage activation and chemotaxis. The pathophysiologic importance of various leukotriene derivatives, particularly LTB4, has been well established whereas the actions of prostaglandins in vivo, in particular PGE2, are controversial. Numerous anti-inflammatory drugs such as glucocorticoids and salicylic acid derivatives have been successfully used to treat intestinal inflammation. One possible mechanism of action is the modulation of arachidonic acid metabolism and thus regulation of the genesis of active inflammatory mediators." @default.
- W119953189 created "2016-06-24" @default.
- W119953189 creator A5041644373 @default.
- W119953189 creator A5059435501 @default.
- W119953189 date "1990-08-01" @default.
- W119953189 modified "2023-09-26" @default.
- W119953189 title "[The role of arachidonic acid metabolism in the pathophysiology of chronic inflammatory intestinal diseases]." @default.
- W119953189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2210793" @default.
- W119953189 hasPublicationYear "1990" @default.
- W119953189 type Work @default.
- W119953189 sameAs 119953189 @default.
- W119953189 citedByCount "0" @default.
- W119953189 crossrefType "journal-article" @default.
- W119953189 hasAuthorship W119953189A5041644373 @default.
- W119953189 hasAuthorship W119953189A5059435501 @default.
- W119953189 hasConcept C10162356 @default.
- W119953189 hasConcept C126322002 @default.
- W119953189 hasConcept C134018914 @default.
- W119953189 hasConcept C181199279 @default.
- W119953189 hasConcept C203014093 @default.
- W119953189 hasConcept C2776042228 @default.
- W119953189 hasConcept C2776452501 @default.
- W119953189 hasConcept C2776685179 @default.
- W119953189 hasConcept C2776914184 @default.
- W119953189 hasConcept C2777983669 @default.
- W119953189 hasConcept C2778078955 @default.
- W119953189 hasConcept C2778260677 @default.
- W119953189 hasConcept C2779134260 @default.
- W119953189 hasConcept C2780479503 @default.
- W119953189 hasConcept C2910924620 @default.
- W119953189 hasConcept C55493867 @default.
- W119953189 hasConcept C71924100 @default.
- W119953189 hasConcept C86803240 @default.
- W119953189 hasConceptScore W119953189C10162356 @default.
- W119953189 hasConceptScore W119953189C126322002 @default.
- W119953189 hasConceptScore W119953189C134018914 @default.
- W119953189 hasConceptScore W119953189C181199279 @default.
- W119953189 hasConceptScore W119953189C203014093 @default.
- W119953189 hasConceptScore W119953189C2776042228 @default.
- W119953189 hasConceptScore W119953189C2776452501 @default.
- W119953189 hasConceptScore W119953189C2776685179 @default.
- W119953189 hasConceptScore W119953189C2776914184 @default.
- W119953189 hasConceptScore W119953189C2777983669 @default.
- W119953189 hasConceptScore W119953189C2778078955 @default.
- W119953189 hasConceptScore W119953189C2778260677 @default.
- W119953189 hasConceptScore W119953189C2779134260 @default.
- W119953189 hasConceptScore W119953189C2780479503 @default.
- W119953189 hasConceptScore W119953189C2910924620 @default.
- W119953189 hasConceptScore W119953189C55493867 @default.
- W119953189 hasConceptScore W119953189C71924100 @default.
- W119953189 hasConceptScore W119953189C86803240 @default.
- W119953189 hasIssue "4" @default.
- W119953189 hasLocation W1199531891 @default.
- W119953189 hasOpenAccess W119953189 @default.
- W119953189 hasPrimaryLocation W1199531891 @default.
- W119953189 hasRelatedWork W119953189 @default.
- W119953189 hasRelatedWork W1973088723 @default.
- W119953189 hasRelatedWork W2011553051 @default.
- W119953189 hasRelatedWork W2045361766 @default.
- W119953189 hasRelatedWork W2080062014 @default.
- W119953189 hasRelatedWork W2085638846 @default.
- W119953189 hasRelatedWork W2102502831 @default.
- W119953189 hasRelatedWork W2118714297 @default.
- W119953189 hasRelatedWork W4220994856 @default.
- W119953189 hasRelatedWork W960494258 @default.
- W119953189 hasVolume "18" @default.
- W119953189 isParatext "false" @default.
- W119953189 isRetracted "false" @default.
- W119953189 magId "119953189" @default.
- W119953189 workType "article" @default.