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- W119975303 abstract "Apoptosis is a highly organized, energy-dependent program by which multicellular organisms eliminate damaged, superfluous, and potentially harmful cells. While caspases are the most prominent group of proteases involved in the apoptotic process, the role of lysosomes and, more particularly, of lysosomal cathepsins in cell death has only been recently unmasked. The release of cathepsins from the lysosomal lumen to the cytosol is a precondition for their participation in the regulation of apoptosis and has been described in response to a variety of death stimuli such as members of the cell-surface TNF receptor family, chemotherapeutic drugs, and nonreceptor-mediated apoptotic agents. This lysosomal membrane permeabilization often relies on the activation of the intrinsic apoptosis pathway, which involves mitochondrial membrane permeabilization and the consequent release of the proapoptotic mitochondrial proteins into the cytosol. These factors lead to caspase activation and, finally, cell death. The aim of this chapter, emphasizing the role of lysosomal proteases in apoptosis, is to summarize past and recent findings that provide an insight into the mechanisms by which these hydrolases modulate apoptosis and also those that strongly argue for their role in the control of pathogenic cell dismantling." @default.
- W119975303 created "2016-06-24" @default.
- W119975303 creator A5008268675 @default.
- W119975303 date "2009-01-01" @default.
- W119975303 modified "2023-09-24" @default.
- W119975303 title "Lysosomal Proteases in Cell Death" @default.
- W119975303 cites W1486197790 @default.
- W119975303 cites W1522763255 @default.
- W119975303 cites W1528170782 @default.
- W119975303 cites W1543932951 @default.
- W119975303 cites W1546743612 @default.
- W119975303 cites W1560487523 @default.
- W119975303 cites W1576530886 @default.
- W119975303 cites W1660893922 @default.
- W119975303 cites W1719651482 @default.
- W119975303 cites W1890027265 @default.
- W119975303 cites W1963819382 @default.
- W119975303 cites W1963971594 @default.
- W119975303 cites W1964198812 @default.
- W119975303 cites W1964785787 @default.
- W119975303 cites W1967112165 @default.
- W119975303 cites W1967127968 @default.
- W119975303 cites W1968295892 @default.
- W119975303 cites W1969533704 @default.
- W119975303 cites W1969792769 @default.
- W119975303 cites W1972175837 @default.
- W119975303 cites W1972264725 @default.
- W119975303 cites W1977260572 @default.
- W119975303 cites W1978527995 @default.
- W119975303 cites W1978841975 @default.
- W119975303 cites W1982592578 @default.
- W119975303 cites W1983091454 @default.
- W119975303 cites W1983495993 @default.
- W119975303 cites W1984073321 @default.
- W119975303 cites W1984145308 @default.
- W119975303 cites W1984254677 @default.
- W119975303 cites W1985512022 @default.
- W119975303 cites W1987876460 @default.
- W119975303 cites W1988967065 @default.
- W119975303 cites W1991501592 @default.
- W119975303 cites W1994596867 @default.
- W119975303 cites W1994874844 @default.
- W119975303 cites W1996299899 @default.
- W119975303 cites W1996463118 @default.
- W119975303 cites W2001724432 @default.
- W119975303 cites W2005375686 @default.
- W119975303 cites W2006233042 @default.
- W119975303 cites W2006456311 @default.
- W119975303 cites W2009266531 @default.
- W119975303 cites W2012361667 @default.
- W119975303 cites W2013991432 @default.
- W119975303 cites W2015015357 @default.
- W119975303 cites W2015052614 @default.
- W119975303 cites W2017208305 @default.
- W119975303 cites W2017661157 @default.
- W119975303 cites W2018692481 @default.
- W119975303 cites W2019363409 @default.
- W119975303 cites W2019631673 @default.
- W119975303 cites W2021230433 @default.
- W119975303 cites W2021722828 @default.
- W119975303 cites W2022520367 @default.
- W119975303 cites W2023750468 @default.
- W119975303 cites W2024420787 @default.
- W119975303 cites W2028520206 @default.
- W119975303 cites W2030723908 @default.
- W119975303 cites W2030772295 @default.
- W119975303 cites W2035329189 @default.
- W119975303 cites W2035831296 @default.
- W119975303 cites W2036191765 @default.
- W119975303 cites W2036799215 @default.
- W119975303 cites W2037550111 @default.
- W119975303 cites W2037827452 @default.
- W119975303 cites W2039941216 @default.
- W119975303 cites W2040107841 @default.
- W119975303 cites W2042141266 @default.
- W119975303 cites W2043287922 @default.
- W119975303 cites W2044247344 @default.
- W119975303 cites W2044627396 @default.
- W119975303 cites W2045229530 @default.
- W119975303 cites W2047511787 @default.
- W119975303 cites W2048953882 @default.
- W119975303 cites W2050900373 @default.
- W119975303 cites W2051945714 @default.
- W119975303 cites W2055793916 @default.
- W119975303 cites W2058616596 @default.
- W119975303 cites W2060137381 @default.
- W119975303 cites W2060476837 @default.
- W119975303 cites W2061181299 @default.
- W119975303 cites W2061306124 @default.
- W119975303 cites W2061867766 @default.
- W119975303 cites W2066810740 @default.
- W119975303 cites W2068023718 @default.
- W119975303 cites W2071966723 @default.
- W119975303 cites W2073788301 @default.
- W119975303 cites W2075493559 @default.
- W119975303 cites W2076296181 @default.
- W119975303 cites W2082925865 @default.
- W119975303 cites W2083944684 @default.