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- W1200115088 abstract "Publisher Summary There are several indications that the observations on mitochondria1 spaces are not amenable to simplistic explanations. Although data from different laboratories appear to be in agreement and support the two-space model, the size of the sucrose-permeable space proves to be extremely variable when measured on the same material, with similar procedures, and sometimes in the same laboratory. Although measurements of the sucrose-permeable space have generally led to an interpretation based on a two-space model, experimental details and specific results differ fundamentally. The model can be tailored to fit the data only after extensive additions or provisos. One-space model, the only alternative to the two-space model, can also explain the rapid penetration of the part of the mitochondrial space and its apparent nonosmotic behavior. The one-space model appears to be compatible with most of the reported results. On the basis of this model; however, it is difficult to explain the exit of sucrose against an apparent concentration gradient when mitochondria are shifted from a high to a low concentration of sucrose. Because no alternative models have been proposed, further experiments are needed either to allow a clear-cut choice between the two models or to propose an alternative. More attention to experimental variability and the complete reporting of more significant parameters will help to throw light on the questions analyzed." @default.
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- W1200115088 date "1972-01-01" @default.
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- W1200115088 title "Mitochondrial Compartments: A Comparison of Two Models" @default.
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