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- W1201243313 startingPage "76" @default.
- W1201243313 abstract "目的 L-精氨酸·L门冬氨酸盐具有抑制血小板聚集和血栓形成的作用,本文观察它在体外对GP Iib/IIIa单抗FITC-PAC-1与洗涤家兔血小板结合的影响和体内给药对大鼠血小板活性物质的影响,以探讨其作用机制.方法用流式细胞仪测定抗体与活化血小板的结合;用比色法测定血清NO浓度;用放免法测定cAMP, TXA2和PGI2水平.结果 L-精氨酸·L门冬氨酸盐30 mg·kg-1灌胃给药,可明显增加大鼠血浆NO浓度和大鼠主动脉段体外培养上清液中6-keto-PGF1α水平,但对血浆中TXB2和6-keto-PGF1α水平和血小板内cAMP的含量无明显影响,而乙酰水杨酸则明显降低血清TXB2和6-keto-PGF1α水平.L-精氨酸*L门冬氨酸盐100 μmol·L-1在体外可明显减少GP Iib/IIIa单抗FITC-PAC-1与血小板的结合.结论 L-精氨酸·L-门冬氨酸盐抑制血小板聚集和抗血栓形成的功效可能通过增加血管内皮细胞释放NO和PGI2,继而阻止血小板活化来介导,而与花生四烯酸及cAMP代谢途径无密切关系." @default.
- W1201243313 created "2016-06-24" @default.
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- W1201243313 date "2004-01-01" @default.
- W1201243313 modified "2023-09-23" @default.
- W1201243313 title "L-精氨酸·L-门冬氨酸盐抑制血小板功能的可能途径" @default.
- W1201243313 hasPublicationYear "2004" @default.
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